Evidence map›Paper›PMID 37508555›Full record

ArticleCells2023

Expression of Interferon Regulatory Factor 8 (IRF8) and Its Association with Infections in Dialysis Patients.

Justa Friebus-Kardash, Fei Kuang, Tobias Peitz, Thamer A Hamdan, Ute Eisenberger, Kristina Boss, Andreas Kribben, Karl Sebastian Lang, Michael Jahn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Justa Friebus-KardashDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, 47057 Essen, Germany.ORCID 0000-0002-6747-1240
Fei KuangInstitute of Immunology, University Hospital Essen, University of Duisburg-Essen, 47057 Essen, Germany.
Tobias PeitzDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, 47057 Essen, Germany.
Thamer A HamdanInstitute of Immunology, University Hospital Essen, University of Duisburg-Essen, 47057 Essen, Germany.
Ute EisenbergerDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, 47057 Essen, Germany.
Kristina BossDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, 47057 Essen, Germany.
Andreas KribbenDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, 47057 Essen, Germany.
Karl Sebastian LangInstitute of Immunology, University Hospital Essen, University of Duisburg-Essen, 47057 Essen, Germany.
Michael JahnDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, 47057 Essen, Germany.ORCID 0000-0002-7493-205X
University of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients on dialysis have dysfunctions of innate and adaptive immune system responses. The transcriptional factor IRF8 (interferon regulatory factor 8) is primarily expressed in plasmacytoid cells (pDCs) and myeloid dendritic cells (mDCs), playing a crucial role in the maturation of dendritic cells, monocytes, and macrophages, and contributing to protection against bacterial infections. The current study analyzed the expression patterns of IRF8 and assessed its association with the risk of infections in 79 dialysis patients compared to 44 healthy controls. Different subsets of leukocytes and the intracellular expression of IRF8 were measured using flow cytometry. Compared to the healthy controls, the dialysis patients showed significantly reduced numbers of pDCs and significantly increased numbers of natural killer cells and classical and intermediate monocytes. The dialysis patients exhibited decreased numbers of IRF8-positive dendritic cells (pDC

Indexed as

Interferon Regulatory FactorsRenal DialysisHumansInterferon Regulatory Factor-8LymphocytesMonocytesInterferon Regulatory Factor-8Interferon Regulatory Factorsdendritic cellsdialysisinfectionsinterferon regulatory factor 8 (IRF8)monocytes

Identifiers

PMID37508555
PMCPMC10378315
OpenAlexW4384929476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.