Evidence map›Paper›PMID 37508491›Full record

ArticleCells2023

Oral Delivery of mRNA Vaccine by Plant-Derived Extracellular Vesicle Carriers.

Margherita A C Pomatto, Chiara Gai, Federica Negro, Lucia Massari, Maria Chiara Deregibus, Francesco Giuseppe De Rosa, Giovanni Camussi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Margherita A C PomattoEvoBiotech s.r.l., 10122 Turin, Italy.ORCID 0000-0002-5388-7798
Chiara GaiEvoBiotech s.r.l., 10122 Turin, Italy.ORCID 0000-0002-3443-7417
Federica NegroEvoBiotech s.r.l., 10122 Turin, Italy.
Lucia MassariEvoBiotech s.r.l., 10122 Turin, Italy.
Maria Chiara DeregibusDepartment of Medical Science, University of Turin, A.O.U. Città della Salute e della Scienza di Torino, 10126 Turin, Italy.
Francesco Giuseppe De RosaDepartment of Medical Science, University of Turin, A.O.U. Città della Salute e della Scienza di Torino, 10126 Turin, Italy.ORCID 0000-0001-8338-0130
Giovanni CamussiEvoBiotech s.r.l., 10122 Turin, Italy.ORCID 0000-0003-2795-232X
University of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

mRNA-based vaccines were effective in contrasting SARS-CoV-2 infection. However, they presented several limitations of storage and supply chain, and their parenteral administration elicited a limited mucosal IgA immune response. Extracellular vesicles (EVs) have been recognized as a mechanism of cell-to-cell communication well-preserved in all life kingdoms, including plants. Their membrane confers protection from enzyme degradation to encapsulated nucleic acids favoring their transfer between cells. In the present study, EVs derived from the juice of an edible plant (

Indexed as

COVID-19Extracellular VesiclesAnimalsImmunity, MucosalImmunoglobulin APlantsRatsRNA, MessengerSARS-CoV-2Immunoglobulin ARNA, Messengercapsulecarrierdeliveryextracellular vesiclesmRNAoralplantSARS-CoV-2vaccine

Identifiers

PMID37508491
PMCPMC10378442
OpenAlexW4384037143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.