Evidence map›Paper›PMID 37508476›Full record

ArticleCells2023

Effects of Oral Cannabinoids on Systemic Inflammation and Viral Reservoir Markers in People with HIV on Antiretroviral Therapy: Results of the CTN PT028 Pilot Clinical Trial.

Ralph-Sydney Mboumba Bouassa, Eve Comeau, Yulia Alexandrova, Amélie Pagliuzza, Alexis Yero, Suzanne Samarani, Judy Needham, Joel Singer, Terry Lee, Florian Bobeuf and 10 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

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  11. IFN-γ, IL-17, IL-22American journal of clinical and experimental immunology · 2024
    Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Ralph-Sydney Mboumba BouassaDepartment of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal, Montreal, QC H2X 3Y7, Canada.ORCID 0000-0002-3956-6189
Eve ComeauDepartment of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal, Montreal, QC H2X 3Y7, Canada.ORCID 0000-0002-8414-388X
Yulia AlexandrovaDepartment of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal, Montreal, QC H2X 3Y7, Canada.
Amélie PagliuzzaCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 0A9, Canada.
Alexis YeroDepartment of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal, Montreal, QC H2X 3Y7, Canada.ORCID 0000-0002-7406-8740
Suzanne SamaraniInfectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
Judy NeedhamCIHR Canadian HIV Trials Network, Vancouver, BC V6Z 1Y6, Canada.
Joel SingerCIHR Canadian HIV Trials Network, Vancouver, BC V6Z 1Y6, Canada.
Terry LeeCIHR Canadian HIV Trials Network, Vancouver, BC V6Z 1Y6, Canada.
Florian BobeufDepartment of Medicine, Division of Infectious Diseases and Chronic Viral Illness Service, McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
Claude VertzagiasDepartment of Medicine, Division of Infectious Diseases and Chronic Viral Illness Service, McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
Giada SebastianiInfectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.ORCID 0000-0003-2655-8283
Shari MargoleseCIHR Canadian HIV Trials Network, Vancouver, BC V6Z 1Y6, Canada.
Enrico MandarinoCIHR Canadian HIV Trials Network, Vancouver, BC V6Z 1Y6, Canada.
Marina B KleinInfectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
Bertrand LebouchéInfectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.ORCID 0000-0002-1273-9393
Jean-Pierre RoutyInfectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.ORCID 0000-0001-9897-7589
Nicolas ChomontCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 0A9, Canada.
Cecilia T CostiniukInfectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.ORCID 0000-0002-4547-714X
Mohammad-Ali JenabianDepartment of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal, Montreal, QC H2X 3Y7, Canada.ORCID 0000-0003-4321-9777
McGill University Health Centre · CAUniversité du Québec à Montréal · CACentre Hospitalier de l’Université de Montréal · CAHIV Legal Network · CASt. Paul's Hospital · CAUniversity of British Columbia · CA

Funding

CIHR CTN PT028
6 · The paper itself

Abstract

Chronic HIV infection is characterized by persistent inflammation despite antiretroviral therapy (ART). Cannabinoids may help reduce systemic inflammation in people with HIV (PWH). To assess the effects of oral cannabinoids during HIV, ten PWH on ART were randomized (

Indexed as

CannabidiolCannabinoidsHIV InfectionsCapsulesHumansInflammationMaleRNASemenCannabidiolCannabinoidsCapsulesRNAcannabidiol (CBD)cannabinoidsHIV reservoirimmune responsesystemic inflammationΔ9-tetrahydrocannabinol (THC)

Identifiers

PMID37508476
PMCPMC10378564
OpenAlexW4383695189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.