Evidence map›Paper›PMID 37508353›Full record

ReviewBiology2023

MicroRNA (miR)-124: A Promising Therapeutic Gateway for Oncology.

Karthik Gourishetti, Vignesh Balaji Easwaran, Youssef Mostakim, K Sreedhara Ranganath Pai, Deepak Bhere

Open access · goldAbstract readReview
In one paragraph

Review in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Karthik GourishettiBiotherapeutics Laboratory, School of Medicine Columbia, University of South Carolina, Columbia, SC 29209, USA.ORCID 0000-0001-5262-0883
Vignesh Balaji EaswaranDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India.ORCID 0000-0002-6394-5381
Youssef MostakimBiotherapeutics Laboratory, School of Medicine Columbia, University of South Carolina, Columbia, SC 29209, USA.
K Sreedhara Ranganath PaiDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India.ORCID 0000-0002-2017-9533
Deepak BhereBiotherapeutics Laboratory, School of Medicine Columbia, University of South Carolina, Columbia, SC 29209, USA.ORCID 0000-0003-4142-5518
University of South Carolina · USManipal Academy of Higher Education · IN

Funding

microRNA therapies for advanced brain tumorsR00CA245030 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BHERE, DEEPAK · 2022 to 2024
$828k
NCI NIH HHS R00 CA245030NCI NIH HHS R00CA245030
6 · The paper itself

Abstract

MicroRNA (miR) are a class of small non-coding RNA that are involved in post-transcriptional gene regulation. Altered expression of miR has been associated with several pathological conditions. MicroRNA-124 (miR-124) is an abundantly expressed miR in the brain as well as the thymus, lymph nodes, bone marrow, and peripheral blood mono-nuclear cells. It plays a key role in the regulation of the host immune system. Emerging studies show that dysregulated expression of miR-124 is a hallmark in several cancer types and it has been attributed to the progression of these malignancies. In this review, we present a comprehensive summary of the role of miR-124 as a promising therapeutic gateway in oncology.

Indexed as

cancer treatmentclinical implicationsmicroRNA therapeuticsmiR-124oncology

Identifiers

PMID37508353
PMCPMC10376116
OpenAlexW4382724826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.