Evidence map›Paper›PMID 37508258›Full record

ArticleAntibiotics (Basel, Switzerland)2023

Assessment of Antimicrobial Consumption in Multi-Field Hospitals with Pediatric Inpatients: Conventional vs. Novel Pediatric-Adjusted Methodologies.

Svetlana Rachina, Yuliya Belkova, Roman Kozlov, Vladimir Mladov, Vladimir Mishchenko, Alla Andreeva, Olga Domanskaya, Ulyana Portnjagina, Anastasiia Dushina, Khadizhat Zainalabidova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Svetlana RachinaHospital Therapy Department No. 2, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia.ORCID 0000-0002-3329-7846
Yuliya BelkovaDepartment of Clinical Pharmacology, Smolensk State Medical University, 214019 Smolensk, Russia.ORCID 0000-0002-4422-6517
Roman KozlovInstitute of Antimicrobial Chemotherapy, Smolensk State Medical University, 214019 Smolensk, Russia.ORCID 0000-0001-8728-1113
Vladimir MladovFaculty of Applied Mathematics and Control Processes, St. Petersburg State University, 199034 St. Petersburg, Russia.
Vladimir MishchenkoFederal Centre of Traumatology, Orthopedics and Endoprosthesis Replacement, 214019 Smolensk, Russia.ORCID 0000-0003-4114-4425
Alla AndreevaSmolensk Regional Clinical Hospital, 214018 Smolensk, Russia.
Olga DomanskayaKuzbas Children's Clinical Hospital n.a. Professor Y.E. Malachovskiy, 654063 Novokuznetsk, Russia.
Ulyana PortnjaginaDepartment of Internal Medicine and General Medical Practice (Family Medicine), North-Eastern Federal University, 677007 Yakutsk, Russia.
Anastasiia DushinaInstitute of Engineering Physics for Biomedicine, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 115409 Moscow, Russia.ORCID 0000-0001-8296-6172
Khadizhat ZainalabidovaHospital Therapy Department No. 2, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia.
Sechenov University · RUSmolensk State Medical University · RUInstitute of Engineering Physics · RUNorth-Eastern Federal University · RURegional State Budgetary Healthcare Institution "Smolensk Regional Clinical Hospital" · RUSt Petersburg University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundthe objective of this study was to propose a methodology for the assessment of antimicrobial consumption (AMC) in pediatric inpatients and to estimate variances in consumption levels in multi-field hospitals with pediatric inpatients, calculated by means of the pediatric-adjusted methodology vs. the conventional methodology.

methodsthe pediatric-adjusted methodology based on the conventional ATC/DDD method and children's DDDs (cDDD) for antimicrobials were proposed and validated in a series of probabilistic sensitivity analyses of real clinical data extracted from the receipt notes of three multi-field hospitals. Differences in AMC in multi-field hospitals with pediatric inpatients, calculated by means of the proposed methodology vs. the conventional methodology, were assessed for a virtual cohort of inpatients, with the pediatric share increasing by 1%.

resultsin children ≤12 years old, assessment by the standard methodology resulted in a 59% underestimation of AMC from the levels based on prescribed doses, vs. a 25% underestimation for the proposed methodology. In a mixed-age virtual population of inpatients, the underestimation of consumption levels rose to 321% for the ATC/DDD methodology compared to the proposed one.

conclusionsthe proposed methodology demonstrated a higher accuracy of AMC estimates compared to the conventional one and can be considered for the quantification of antimicrobial utilization in pediatric institutions and multi-field hospitals with a substantial share of pediatric inpatients.

Indexed as

antimicrobial agentATC/DDD methodologyconsumptionDDDdefined daily dosehospitalpediatric

Identifiers

PMID37508258
PMCPMC10376229
OpenAlexW4383724498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.