ReviewAntioxidants (Basel, Switzerland)2023
Oxidative Stress in Obstructive Sleep Apnea Syndrome: Putative Pathways to Hearing System Impairment.
Review in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 19 citations in OpenAlex.
- Review
- Intratympanic injection of human umbilical cord mesenchymal stem cell derived small extracellular vesicles for refractory sudden sensorineural hearing loss: a Phase 1 trial.Stem cell research & therapy · 2026Article
- Obstructive Sleep Apnea and Arrhythmia: A Narrative Review of Arrhythmogenic Mechanisms.Diagnostics (Basel, Switzerland) · 2026Review
- Vitamin C mitigates early auditory cortical hyperexcitability and antioxidant imbalance induced by acute intermittent hypoxia.Experimental brain research · 2026Article
- High-Frequency Hearing Loss and Decrease in High-Frequency Hearing Thresholds after Positive Airway Pressure Treatment in Patients with Severe OSA.International archives of otorhinolaryngology · 2026Article
- The Association of Hearing Impairment and Behavioral and Psychological Symptoms in Community-Dwelling Patients with Alzheimer's Disease.Psychology research and behavior management · 2026Article
- Research status and progress on the relationship between obstructive sleep apnea and pulmonary nodules.Frontiers in medicine · 2026Review
- Effect of Continuous Positive Airway Pressure Treatment on Hearing and Inner Ear Function in Patients with Obstructive Sleep Apnoea-Original Research.Medicina (Kaunas, Lithuania) · 2025Article
- Continual hyperoxidation of erythrocytic peroxiredoxin 2 in obstructive sleep apnoea: a possible biomarker of oxidative stress.ERJ open research · 2025Article
- Effects of Continuous Positive Airway Pressure on the Degree of Sleepiness, Functional Quality of Sleep, and Electrophysiological Hearing Responses in Individuals with Obstructive Sleep Apnea.Sleep science (Sao Paulo, Brazil) · 2025Article
- Oxidative Stress and Inflammation in Hypoxemic Respiratory Diseases and Their Comorbidities: Molecular Insights and Diagnostic Advances in Chronic Obstructive Pulmonary Disease and Sleep Apnea.Antioxidants (Basel, Switzerland) · 2025Review
- Triglyceride-glucose index as a predictor of the risk of sarcopenia in elderly patients with OSA: a multicenter study.Diabetology & metabolic syndrome · 2025Article
- Combined exposure to mixed brominated flame retardants on obstructive sleep apnea syndrome in US adults.BMC public health · 2025Article
- TEX10: A Novel Drug Target and Potential Therapeutic Direction for Sleep Apnea Syndrome.Nature and science of sleep · 2025Article
- Relationship between sleep duration and hearing loss among adults aged 20-69: exploration of the U-shaped curve pattern.Frontiers in neuroscience · 2025Article
- The relationships between intermittent hypoxia and oxidative stress in patients with sleep apnea syndrome.Sleep and biological rhythms · 2024Article
- Exploring the bidirectional relationship between sleep disorders and atrial fibrillation: implications for risk stratification and management.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024Review
- Exploring the interplay of depression, sleep quality, and hearing in tinnitus-related handicap: insights from polysomnography and pure-tone audiometry.BMC psychiatry · 2024Article
- Mendelian Randomization Reveals: Triglycerides and Sensorineural Hearing Loss.Bioengineering (Basel, Switzerland) · 2024Article
- Snoring might be a warning sign for metabolic syndrome in nonobese Korean women.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
introductionOSAS is a disease that affects 2% of men and 4% of women of middle age. It is a major health public problem because untreated OSAS could lead to cardiovascular, metabolic, and cerebrovascular complications. The more accepted theory relates to oxidative stress due to intermittent hypoxia, which leads, after an intense inflammatory response through multiple pathways, to endothelial damage. The objective of this study is to demonstrate a correlation between OSAS and hearing loss, the effect of the CPAP on hearing function, and if oxidative stress is also involved in the damaging of the hearing system.
methodsA review of the literature has been executed. Eight articles have been found, where seven were about the correlation between OSAS and the hearing system, and only one was about the CPAP effects. It is noted that two of the eight articles explored the theory of oxidative stress due to intermittent hypoxia.
resultsAll studies showed a significant correlation between OSAS and hearing function (
conclusionsUntreated OSAS affects the hearing system at multiple levels. Oxidative stress due to intermittent hypoxia is the main pathogenetic mechanism of damage. CPAP has no effects (positive or negative) on hearing function. More studies are needed, with the evaluation of extended high frequencies, the execution of vocal audiometry in noisy environments, and the evaluation of potential biomarkers due to oxidative stress.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.