Evidence map›Paper›PMID 37507924›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Response of the Glutathione (GSH) Antioxidant Defense System to Oxidative Injury in Necrotizing Enterocolitis.

Alena Golubkova, Tyler Leiva, Katherine Snyder, Camille Schlegel, Sarah M Bonvicino, Martin-Paul Agbaga, Richard S Brush, Jason M Hansen, Peter F Vitiello, Catherine J Hunter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

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  9. Maternal Western diet increases inflammatory markers and decreases barrier function of offspring inAmerican journal of physiology. Gastrointestinal and liver physiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Alena GolubkovaDivision of Pediatric Surgery, Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-9324-5167
Tyler LeivaDivision of Pediatric Surgery, Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Katherine SnyderDivision of Pediatric Surgery, Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Camille SchlegelDivision of Pediatric Surgery, Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Sarah M BonvicinoLipid Analysis Core, Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Martin-Paul AgbagaLipid Analysis Core, Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Richard S BrushLipid Analysis Core, Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Jason M HansenDepartment of Cell Biology and Physiology, Brigham Young University College of Life Sciences, Provo, UT 84602, USA.
Peter F VitielloSection of Neonatal-Perinatal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0001-5344-9192
Catherine J HunterDivision of Pediatric Surgery, Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-5563-3652
University of Oklahoma Health Sciences Center · USDean McGee Eye Institute · USBrigham Young University · US

Funding

Hyperoxic Modulation of Thioredoxin SignalingR01HL135112 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI VITIELLO, PETER · 2017 to 2021
$2.0M
ROCK, tight junctions and prematurity in the pathogenesis of necrotizing enterocolitis and neonatal sepsis.R01DK133207 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Catherine Jane Hunter · 2023 to 2026
$2.0M
NHLBI NIH HHS R01 HL135112NIDDK NIH HHS R01 DK133207
6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) is a neonatal intestinal disease associated with oxidative stress. The targets of peroxidation and the role of the innate intestinal epithelial antioxidant defense system are ill-defined. We hypothesized that oxidative stress in NEC correlates with oxidized GSH redox potentials, lipid peroxidation, and a dysfunctional antioxidant system.

Indexed as

glutathione peroxidase 4glutathione redox potentialsintestinal epithelial injurylipid peroxidationnecrotizing enterocolitisoxidant agentsoxidative stressredox signaling

Identifiers

PMID37507924
PMCPMC10376622
OpenAlexW4383375674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.