Evidence map›Paper›PMID 37507915›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Topical Absorption of Glutathione-Cyclodextrin Nanoparticle Complex in Healthy Human Subjects Improves Immune Response against

Kayvan Sasaninia, Melissa Kelley, Arbi Abnousian, Ali Badaoui, Logan Alexander, Nisar Sheren, James Owens, Shlok Rajurkar, Brianna Razo-Botello, Abraham Chorbajian and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Pathogenesis of Cutaneous Mycobacterial Infections-International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Kayvan SasaniniaCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.ORCID 0000-0003-4299-3621
Melissa KelleyGraduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA.
Arbi AbnousianCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Ali BadaouiCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Logan AlexanderCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Nisar SherenCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.ORCID 0000-0002-3617-7938
James OwensCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Shlok RajurkarDivision of Biological Sciences, University of California Berkeley, Berkeley, CA 94720, USA.
Brianna Razo-BotelloCollege of Natural and Agricultural Science, University of California Riverside, Riverside, CA 92521, USA.
Abraham ChorbajianCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Sonyeol YoonCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Sanya DhamaKeck Science Department, Pitzer College, Claremont, CA 91711, USA.
Edith AvitiaWesternU Center for Clinical Research, Western University of Health Sciences, Pomona, CA 91766, USA.
Cesar OchoaWesternU Center for Clinical Research, Western University of Health Sciences, Pomona, CA 91766, USA.
Ray YutaniCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Vishwanath VenketaramanCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.ORCID 0000-0002-2586-1160
Western University of Health Sciences · USPitzer College · USUniversity of California, Berkeley · USUniversity of California, Riverside · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glutathione (GSH) is an important intracellular antioxidant responsible for neutralizing reactive oxygen species (ROS). Our laboratory previously demonstrated that the oral administration of liposomal GSH improves immune function against mycobacterium infections in healthy patients along with patients with HIV and Type 2 diabetes. We aim to determine if the topical application of a glutathione-cyclodextrin nanoparticle complex (GSH-CD) confers a therapeutic effect against mycobacterium infections. In our study, healthy participants received either topical GSH-CD (n = 15) or placebo (n = 15) treatment. Subjects were sprayed four times twice a day for three days topically on the abdomen. Blood draws were collected prior to application, and at 1, 4, and 72 h post-initial topical application. GSH, malondialdehyde (MDA), and cytokine levels were assessed in the processed blood samples of study participants. Additionally, whole blood cultures from study participants were challenged with

Indexed as

cyclodextringlutathionemycobacteriumoxidative stresstopical

Identifiers

PMID37507915
PMCPMC10376088
OpenAlexW4382982882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.