Evidence map›Paper›PMID 37507776›Full record

ArticleCell & bioscience2023

Intensity-dependent gamma electrical stimulation regulates microglial activation, reduces beta-amyloid load, and facilitates memory in a mouse model of Alzheimer's disease.

Qian Liu, Adam Contreras, Muhammad Shan Afaq, Weijian Yang, Daniel K Hsu, Michael Russell, Bruce Lyeth, Theodore P Zanto, Min Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Temporal Interference Stimulation Enhances Neural Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Qian LiuInstitute for Regenerative Cures, Department of Ophthalmology & Vision Science, Department of Dermatology, University of California Davis, Sacramento, CA, 95817, USA.
Adam ContrerasInstitute for Regenerative Cures, Department of Ophthalmology & Vision Science, Department of Dermatology, University of California Davis, Sacramento, CA, 95817, USA.
Muhammad Shan AfaqInstitute for Regenerative Cures, Department of Ophthalmology & Vision Science, Department of Dermatology, University of California Davis, Sacramento, CA, 95817, USA.
Weijian YangDepartment of Electrical and Computer Engineering, University of California, Davis, CA, 95616, USA.
Daniel K HsuInstitute for Regenerative Cures, Department of Ophthalmology & Vision Science, Department of Dermatology, University of California Davis, Sacramento, CA, 95817, USA.
Michael RussellInstitute for Regenerative Cures, Department of Ophthalmology & Vision Science, Department of Dermatology, University of California Davis, Sacramento, CA, 95817, USA.
Bruce LyethDepartment of Neurological Surgery, University of California, Davis, CA, 95616, USA.
Theodore P ZantoNeuroscape, Department of Neurology, University of California San Francisco, San Francisco, CA, 94158, USA. Theodore.Zanto@ucsf.edu.
Min ZhaoInstitute for Regenerative Cures, Department of Ophthalmology & Vision Science, Department of Dermatology, University of California Davis, Sacramento, CA, 95817, USA. minzhao@ucdavis.edu.ORCID http://orcid.org/0000-0002-2500-3035
California Institute for Regenerative Medicine · USNeurological Surgery · USUniversity of California, Davis · USUniversity of California, San Francisco · US

Funding

Feasibility gamma stimulation to reduce beta-amyloid load across speciesR21AG060335 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZANTO, THEODORE P, ZHAO, MIN · 2018 to 2019
$439k
NIA NIH HHS R21 AG060335NIA NIH HHS R21AG060335
6 · The paper itself

Abstract

backgroundGamma sensory stimulation may reduce AD-specific pathology. Yet, the efficacy of alternating electrical current stimulation in animal models of AD is unknown, and prior research has not addressed intensity-dependent effects.

methodsThe intensity-dependent effect of gamma electrical stimulation (GES) with a sinusoidal alternating current at 40 Hz on Aβ clearance and microglia modulation were assessed in 5xFAD mouse hippocampus and cortex, as well as the behavioral performance of the animals with the Morris Water Maze.

resultsOne hour of epidural GES delivered over a month significantly (1) reduced Aβ load in the AD brain, (2) increased microglia cell counts, decreased cell body size, increased length of cellular processes of the Iba1 + cells, and (3) improved behavioral performance (learning & memory). All these effects were most pronounced when a higher stimulation current was applied.

conclusionThe efficacy of GES on the reduction of AD pathology and the intensity-dependent feature provide guidance for the development of this promising therapeutic approach.

Indexed as

5xFAD mouseAlternating current stimulationAlzheimer’s diseaseAβBeta amyloidGamma waveLearning and memoryMicroglia

Identifiers

PMID37507776
PMCPMC10386209
OpenAlexW4385349326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.