Evidence map›Paper›PMID 37507743›Full record

ArticleItalian journal of pediatrics2023

Interleukin-37 is involved in the immunopathogenesis of infectious mononucleosis.

Mingsheng Zhao, Li Ma, Huihui Jiang, Yufeng Gu, Xin Yang, Riming Liu, Chengming Sun, Yulan Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Italian journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mingsheng Zhao *Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China.ORCID http://orcid.org/0000-0001-6182-4247
Li Ma *Center for Laboratory Diagnosis, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China.
Huihui JiangCenter for Laboratory Diagnosis, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China.
Yufeng GuCenter for Laboratory Diagnosis, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China.
Xin YangCenter for Laboratory Diagnosis, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China.
Riming LiuCenter for Laboratory Diagnosis, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China.
Chengming SunCenter for Laboratory Diagnosis, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China.
Yulan LiCenter for Laboratory Diagnosis, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China.

Funding

Key Technology Research and Development Program of Shandong 2019JZZY011018Lin He's New Medicine and Clinical Translation Academician Workstation Research Fund JYHL2019MS18
6 · The paper itself

Abstract

backgroundMultiple immunopathological responses to viruses are observed in infectious mononucleosis (IM), a manifestation of primary infection with Epstein-Barr virus (EBV). Protective effects of the negative immunoregulatory molecule interleukin-37 (IL-37) have been observed in various bacterial and viral infections. However, the function of IL-37 in IM remains unknown.

methodsFlow cytometry and enzyme-linked immunosorbent assay (ELISA) were used to determine the expression of IL-37 in the peripheral blood of patients diagnosed with IM, and the variation of lymphocyte subsets. Furthermore, the associations between IL-37 expression and the percentage of lymphocyte subgroups were analyzed.

resultsPatients with IM had severe immune dysfunction. The control group had a lower expression of IL-37 than the patients with IM. There were significant associations between IL-37 expression and both the proportion of CD3

conclusionsIL-37 may affect the immune pathogenesis of patients with IM infected with EBV, and may have immunotherapeutic benefit for EBV-associated illnesses.

Indexed as

Epstein-Barr Virus InfectionsInfectious MononucleosisCD8-Positive T-LymphocytesHerpesvirus 4, HumanHumansInterleukinsInterleukinsCD3 + T cellsEpstein–Barr virusInfectious mononucleosisInterleukin-37

Identifiers

PMID37507743
PMCPMC10386628

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.