Evidence map›Paper›PMID 37507475›Full record

ArticleScientific reports2023

Loss of Krüppel-like factor 9 deregulates both physiological gene expression and development.

Laura Drepanos, Ian M Gans, Janelle Grendler, Sophia Guitar, J Heath Fuqua, Nathaniel J Maki, Andrea R Tilden, Joel H Graber, James A Coffman

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Laura DrepanosColby College, Waterville, ME, USA.
Ian M GansMDI Biological Laboratory, Salisbury Cove, ME, USA.
Janelle GrendlerMDI Biological Laboratory, Salisbury Cove, ME, USA.
Sophia GuitarMDI Biological Laboratory, Salisbury Cove, ME, USA.
J Heath FuquaMDI Biological Laboratory, Salisbury Cove, ME, USA.
Nathaniel J MakiMDI Biological Laboratory, Salisbury Cove, ME, USA.
Andrea R TildenColby College, Waterville, ME, USA.
Joel H GraberMDI Biological Laboratory, Salisbury Cove, ME, USA.
James A CoffmanMDI Biological Laboratory, Salisbury Cove, ME, USA. jcoffman@mdibl.org.
Mount Desert Island Biological Laboratory · USColby College · USUniversity of Maine · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI Dustin Lynn Updike · 2012 to 2026
$60.0M
Understanding the role of thyroid hormone signaling during axolotl limb regenerationP20GM104318 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI DRUMMOND, IAIN A. · 2013 to 2023
$23.0M
Environmental arsenic, immunoregulation, and viral disease riskR21ES033303 · NIEHS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI COFFMAN, JAMES A · 2022 to 2023
$450k
Gene regulatory circuitry underlying the dynamic control of glucocorticoid signalingR03HD099468 · NICHD · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI COFFMAN, JAMES A · 2019 to 2020
$166k
NICHD NIH HHS R03 HD099468NIEHS NIH HHS R21 ES033303NIGMS NIH HHS P20 GM103423NIGMS NIH HHS P20 GM104318
6 · The paper itself

Abstract

Krüppel-like factor 9 (Klf9) is a ubiquitously expressed transcription factor that is a feedforward regulator of multiple stress-responsive and endocrine signaling pathways. We previously described how loss of Klf9 function affects the transcriptome of zebrafish larvae sampled at a single time point 5 days post-fertilization (dpf). However, klf9 expression oscillates diurnally, and the sampled time point corresponded to its expression nadir. To determine if the transcriptomic effects of the klf9

Indexed as

Kruppel-Like Transcription FactorsZebrafishAnimalsGene ExpressionGene Expression RegulationRNA, MessengerKruppel-Like Transcription FactorsRNA, Messenger

Identifiers

PMID37507475
PMCPMC10382561
OpenAlexW4385343988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.