Evidence map›Paper›PMID 37507448›Full record

ArticleScientific reports2023

Rejuvenating effects of young extracellular vesicles in aged rats and in cellular models of human senescence.

Lilian Grigorian Shamagian, Russell G Rogers, Kristin Luther, David Angert, Antonio Echavez, Weixin Liu, Ryan Middleton, Travis Antes, Jackelyn Valle, Mario Fourier and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Multicellular senescence programs in the aged heart.Journal of molecular and cellular cardiology plus · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Lilian Grigorian ShamagianCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA. LGrigorian@cibercv.es.
Russell G RogersCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Kristin LutherCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
David AngertCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Antonio EchavezCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Weixin LiuCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Ryan MiddletonCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Travis AntesCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Jackelyn ValleCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Mario FourierCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Liz SanchezCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Eva JaghatspanyanCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Javier MariscalSamuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA.
Rui ZhangCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Eduardo MarbánCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
Cedars-Sinai Medical Center · USSamueli Institute · US

Funding

Exosome-mediated cardioprotection and regenerationR01HL124074 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI MARBAN, EDUARDO · 2014 to 2021
$4.0M
NHLBI NIH HHS R01 HL124074
6 · The paper itself

Abstract

Rejuvenation of an old organism was achieved in heterochronic parabiosis experiments, implicating different soluble factors in this effect. Extracellular vesicles (EVs) are the secretory effectors of many cells, including cardiosphere-derived cells (CDCs) with demonstrated anti-senescent effect. 1. To determine the role of EVs (versus other blood fractions) on the rejuvenating effect of the young blood. 2. To evaluate the anti-aging properties of therapeutically administered EVs secreted by young-CDCs in an old organism. Neonatal blood fractioned in 4 components (whole blood, serum, EV-depleted serum and purified EVs) was used to treat old human cardiac stromal cells (CSPCs). CDCs were generated from neonatal rat hearts and the secreted CDC-EVs were purified. CDC-EVs were then tested in naturally-aged rats, using monthly injections over 4-months period. For validation in human samples, pediatric CDC-EVs were tested in aged human CSPCs and progeric fibroblasts. While the purified EVs reproduced the rejuvenating effects of the whole blood, CSPCs treated with EV-depleted serum exhibited the highest degree of senescence. Treatment with young CDC-EVs induce structural and functional improvements in the heart, lungs, skeletal muscle, and kidneys of old rats, while favorably modulating glucose metabolism and anti-senescence pathways. Lifespan was prolonged. EVs secreted by young CDCs exert broad-ranging anti-aging effects in aged rodents and in cellular models of human senescence. Our work not only identifies CDC-EVs as possible therapeutic candidates for a wide range of age-related pathologies, but also raises the question of whether EVs function as endogenous modulators of senescence.

Indexed as

Extracellular VesiclesAgedAgingAnimalsCellular SenescenceChildFibroblastsHeartHumansLungRats

Identifiers

PMID37507448
PMCPMC10382547
OpenAlexW4385344791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.