ArticleNature communications2023
Electrochemical synthesis of biaryls by reductive extrusion from N,N'-diarylureas.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Deep reduction in electrosynthesis.Nature chemistry · 2026Review
- In Silico Isomerization Produces Apt Negative Data for VHTS Validation.Journal of chemical information and modeling · 2026Article
- An efficient computational chemistry approach to generating negative data for drug discovery pipeline validation.Frontiers in bioinformatics · 2026Article
- Alkali Metal Cations Impact the Selectivity of Radical-Mediated Electrochemical C─H Chlorination.Angewandte Chemie (International ed. in English) · 2025Article
- A Stoichiometric Haloform Coupling for Ester Synthesis with Secondary Alcohols.Angewandte Chemie (International ed. in English) · 2024Article
- Recent Progress on the Synthesis of Bipyridine Derivatives.Molecules (Basel, Switzerland) · 2024Review
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Authors and funding
4 authors.
Funding
Abstract
The synthesis of biaryl compounds by the transition-metal free coupling of arenes is an important contemporary challenge, aiming to avoid the toxicity and cost profiles associated with the metal catalysts commonly used in the synthesis of these pharmaceutically relevant motifs. In this paper, we describe an electrochemical approach to the synthesis of biaryls in which aniline derivatives are coupled through the formation and reduction of a temporary urea linkage. The conformational alignment of the arenes in the N,N'-diaryl urea intermediates promotes C-C bond formation following single-electron reduction. Our optimized conditions are suitable for the synthesis of a variety of biaryls, including sterically hindered examples carrying ortho-substituents, representing complementary reactivity to most metal catalysed methods.
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Registered trials
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