ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023
The VLPFC-Engaged Voluntary Emotion Regulation: Combined TMS-fMRI Evidence for the Neural Circuit of Cognitive Reappraisal.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Characterization of neural networks involved in transdiagnostic emotion dysregulation from a pilot randomized controlled trial of a neurostimulation-enhanced behavioral intervention.Psychiatry research. Neuroimaging · 2024Trial
- Task-evoked network connectivity and pain regulation success in chronic low back pain.Neuroimage. Reports · 2026Article
- Parent-Child Neural Dynamics during a Stressful Task: Probing Associations with Temperament and Anxiety.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Conative inference as a mechanism of allostatic resilience: wanting to be and being to want.Cognitive, affective & behavioral neuroscience · 2026Review
- Functional connectivity of the cognitive emotion regulation network in partially sleep-deprived individuals using an emotional arrows task: potential age-dependent effects.Brain imaging and behavior · 2026Article
- The role of the subcortical structures in subthreshold depression: evidence from static and dynamic functional connectivity.Brain structure & function · 2026Article
- Ventrolateral prefrontal-amygdala repetitive transcranial magnetic stimulation (rTMS) modulation of impulsivity in borderline personality disorder: a proof-of-concept study.Scientific reports · 2026Article
- Differential emotional responses and relief mechanisms across social exclusion roles.Cognitive, affective & behavioral neuroscience · 2026Article
- Neural Oscillations Underlying Guilt-Related Modulation of Visual Size Perception.Behavioral sciences (Basel, Switzerland) · 2026Article
- Regulating Negative Autobiographical Memories: An fMRI Investigation of Reappraisal and Distraction in Middle-aged and Older Adults.Journal of cognitive neuroscience · 2026Article
- A comparison of a multivariate neural pattern versus amygdala response for regulation of negative emotion.Social cognitive and affective neuroscience · 2026Article
- Emotion regulation modulates subsequent control of unwanted memories.Social cognitive and affective neuroscience · 2026Article
- State-dependent modulation of brain co-activation patterns induced by individually targeted VLPFC stimulation during viewing emotional film clips.Frontiers in human neuroscience · 2026Article
- Neurophysiological Markers of Regulation Success in Everyday Life in Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- A dual-fMRI investigation of interpersonal emotion regulation: Predicting strategy selection and implementation success from effective brain connectivity.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Fronto-cingulate gamma synchrony predicts deep brain stimulation response in treatment-resistant depression: preliminary evidence.Journal of psychiatry & neuroscience : JPN · 2026Article
- Fronto-parietal oscillatory dynamics of emotion regulation as a function of adult attachment orientations.Frontiers in human neuroscience · 2026Article
- Corticolimbic structure-function coupling is sensitive to childhood adversity and buffers adversity-related symptoms during development.bioRxiv : the preprint server for biology · 2025Article
- Neural and physiological correlates of parent-child observational threat extinction.Scientific reports · 2025Article
- Dissociating the Role of Dorsolateral Prefrontal Cortex and Ventrolateral Prefrontal Cortex in Cognitive Control in Depression: A Combined HD-tDCS and fNIRS Study.Brain topography · 2025Article
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Authors and funding
7 authors.
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Abstract
A clear understanding of the neural circuit underlying emotion regulation (ER) is important for both basic and translational research. However, a lack of evidence based on combined neuroimaging and neuromodulation techniques calls into question (1) whether the change of prefrontal-subcortical activity intrinsically and causally contributes to the ER effect; and (2) whether the prefrontal control system directly modulates the subcortical affective system. Accordingly, we combined fMRI recordings with transcranial magnetic stimulation (TMS) to map the causal connections between the PFC and subcortical affective structures (amygdala and insula). A total of 117 human adult participants (57 males and 60 females) were included in the study. The results revealed that TMS-induced ventrolateral PFC (VLPFC) facilitation led to enhanced activity in the VLPFC and ventromedial PFC (VMPFC) as well as attenuated activity in the amygdala and insula during reappraisal but not during nonreappraisal (i.e., baseline). Moreover, the activated VLPFC intensified the prefrontal-subcortical couplings via the VMPFC during reappraisal only. This study provides combined TMS-fMRI evidence that downregulating negative emotion involves the prefrontal control system suppressing the subcortical affective system, with the VMPFC serving as a crucial hub within the VLPFC-subcortical network, suggesting an indirect pathway model of the ER circuit. Our findings outline potential protocols for improving ER ability by intensifying the VLPFC-VMPFC coupling in patients with mood and anxiety disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.