Evidence map›Paper›PMID 37507159›Full record

ReviewAdvances in microbial physiology2023

Bacterial metabolism and susceptibility to cell wall-active antibiotics.

Megan Renee Keller, Tobias Dörr

Open access · greenAbstract readReview
In one paragraph

Review in Advances in microbial physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
34.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Synergistic Action of Antimicrobial Peptides and Antibiotics.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Bacterial peptidoglycan as a living polymer.Current opinion in chemical biology · 2025
    Review
  9. Article
  10. Review
  11. The role ofJournal of bacteriology · 2024
    Article
  12. Rhodamine 19 Alkyl Esters as Effective Antibacterial Agents.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Megan Renee KellerWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, United States.
Tobias DörrWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, United States; Department of Microbiology, Cornell University, Ithaca, NY, United States; Cornell Institute of Host-Microbe Interactions and Disease, Cornell University, Ithaca, NY, United States. Electronic address: tdoerr@cornell.edu.
Cornell University · US

Funding

Cell envelope stress responses and the mechanism of antibiotic tolerance in Gram-negative pathogensR01AI143704 · NIAID · CORNELL UNIVERSITY · PI DOERR, TOBIAS · 2019 to 2023
$2.0M
NIAID NIH HHS R01 AI143704
6 · The paper itself

Abstract

Bacterial infections are increasingly resistant to antimicrobial therapy. Intense research focus has thus been placed on identifying the mechanisms that bacteria use to resist killing or growth inhibition by antibiotics and the ways in which bacteria share these traits with one another. This work has led to the advancement of new drugs, combination therapy regimens, and a deeper appreciation for the adaptability seen in microorganisms. However, while the primary mechanisms of action of most antibiotics are well understood, the more subtle contributions of bacterial metabolic state to repairing or preventing damage caused by antimicrobials (thereby promoting survival) are still understudied. Here, we review a modern viewpoint on a classical system: examining bacterial metabolism's connection to antibiotic susceptibility. We dive into the relationship between metabolism and antibiotic efficacy through the lens of growth rate, energy state, resource allocation, and the infection environment, focusing on cell wall-active antibiotics.

Indexed as

Anti-Infective AgentsBacterial InfectionsAnti-Bacterial AgentsBacteriaCell WallHumansAnti-Bacterial AgentsAnti-Infective AgentsAntibiotic resistanceAntibiotic toleranceBeta-lactams

Identifiers

PMID37507159
PMCPMC11024984
OpenAlexW4376852019

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.