ArticleChest2023
Race-Specific Spirometry Equations Do Not Improve Models of Dyspnea and Quantitative Chest CT Phenotypes.
Article in Chest, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Race-neutral spirometry reclassification in self-identified Black and White patients.ERJ open research · 2026Article
- Observational
- Race-neutral versus race-specific GLI reference equations on spirometry interpretation in the general population.Scientific reports · 2025Article
- Lung Function Trajectory Using Race-Specific vs Race-Neutral Global Lung Function Initiative Coefficients.JAMA network open · 2025Article
- Comparison of Race-Neutral versus Race-Specific Spirometry Equations for Evaluation of Child Asthma.American journal of respiratory and critical care medicine · 2025Article
- Rethinking the Role of Race in Lung Function: The Shift to Race-Neutral Spirometry Interpretation.Mayo Clinic proceedings · 2024Article
- How do deep-learning models generalize across populations? Cross-ethnicity generalization of COPD detection.Insights into imaging · 2024Article
- Implications of Race Adjustment in Lung-Function Equations.The New England journal of medicine · 2024Article
- Race Adjustment of Pulmonary Function Tests in the Diagnosis and Management of COPD: A Scoping Review.International journal of chronic obstructive pulmonary disease · 2024Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundRace-specific spirometry reference equations are used globally to interpret lung function for clinical, research, and occupational purposes, but inclusion of race is under scrutiny. RESEARCH QUESTION: Does including self-identified race in spirometry reference equation formation improve the ability of predicted FEV STUDY DESIGN AND
methodsUsing data from healthy adults who have never smoked in both the National Health and Nutrition Survey (2007-2012) and COPDGene study cohorts, race-neutral, race-free, and race-specific prediction equations were generated for FEV
resultsRace-specific equations showed no advantage relative to race-neutral or race-free equations in models of quantitative chest CT phenotypes or dyspnea. Race-neutral reference equations reclassified up to 19% of Black participants into more severe GOLD classes, while race-neutral/race-free equations may improve model fit for dyspnea symptoms relative to race-specific equations.
interpretationRace-specific equations offered no advantage over race-neutral/race-free equations in three distinct explanatory models of dyspnea and chest CT scan abnormalities. Race-neutral/race-free reference equations may improve pulmonary disease diagnoses and treatment in populations highly vulnerable to lung disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.