Evidence map›Paper›PMID 37506977›Full record

ArticleThe Journal of allergy and clinical immunology2024

Single-cell profiling of prurigo nodularis demonstrates immune-stromal crosstalk driving profibrotic responses and reversal with nemolizumab.

Feiyang Ma, Mehrnaz Gharaee-Kermani, Lam C Tsoi, Olesya Plazyo, Prasad Chaskar, Paul Harms, Matthew T Patrick, Xianying Xing, Grace Hile, Christophe Piketty and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. IL31 identified as a key genetic risk factor for prurigo nodularis.The Journal of allergy and clinical immunology · 2025
    Pooled it
  2. Immunopathogenesis of itch: an integrative framework for chronic pruritus.JID innovations : skin science from molecules to population health · 2026
    Review
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  14. A single-cell spatial transcriptomic census of human skin anatomy.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Feiyang MaDepartment of Dermatology, University of Michigan, Ann Arbor, Mich.
Mehrnaz Gharaee-KermaniDepartment of Dermatology, University of Michigan, Ann Arbor, Mich.
Lam C TsoiDepartment of Dermatology, University of Michigan, Ann Arbor, Mich; Department of Biostatistics, University of Michigan, Ann Arbor, Mich; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Mich.
Olesya PlazyoDepartment of Dermatology, University of Michigan, Ann Arbor, Mich.
Prasad ChaskarGalderma, Lausanne, Switzerland.
Paul HarmsDepartment of Dermatology, University of Michigan, Ann Arbor, Mich; Department of Pathology, University of Michigan, Ann Arbor, Mich.
Matthew T PatrickDepartment of Dermatology, University of Michigan, Ann Arbor, Mich.
Xianying XingDepartment of Dermatology, University of Michigan, Ann Arbor, Mich.
Grace HileDepartment of Dermatology, University of Michigan, Ann Arbor, Mich.
Christophe PikettyGalderma, Lausanne, Switzerland.
Anne LazzariGalderma, Lausanne, Switzerland.
Wouter Van DelmGalderma, Lausanne, Switzerland.
Emanual MaverakisDepartment of Dermatology, University of California-Davis, Sacramento, Calif.
Mio NakamuraDepartment of Dermatology, University of Michigan, Ann Arbor, Mich.
Robert L ModlinDepartment of Dermatology, University of California-Los Angeles, Calif.
J Michelle KahlenbergDepartment of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Mich; Taubman Medical Research Institute, University of Michigan, Ann Arbor, Mich.
Allison C BilliDepartment of Dermatology, University of Michigan, Ann Arbor, Mich.
Valerie JuliaGalderma, Lausanne, Switzerland.
Jayendra Kumar KrishnaswamyGalderma, Lausanne, Switzerland.
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, Mich; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Mich; Taubman Medical Research Institute, University of Michigan, Ann Arbor, Mich. Electronic address: johanng@med.umich.edu.
University of Michigan · USGalderma (Switzerland) · CHUniversity of California, Davis · USUniversity of California, Los Angeles · US

Funding

Molecular Analysis of the Host Immune Response in LeprosyR01AI022553 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROBERT L MODLIN · 1989 to 2026
$15.7M
Microbiology and Metagenomics CoreP50AR080594 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROBERT L MODLIN · 2022 to 2026
$9.2M
University of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6M
Integrative Biology Approach to Identify and Characterize Roles of lncRNAs Associated with Psoriasis PathologyK01AR072129 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TSOI, LAM CHEUNG · 2017 to 2021
$500k
NIAID NIH HHS R01 AI022553NIAMS NIH HHS K01 AR072129NIAMS NIH HHS P30 AR075043NIAMS NIH HHS P50 AR080594
6 · The paper itself

Abstract

backgroundPrurigo nodularis (PN) is a chronic neuroimmune skin disease characterized by bilaterally distributed pruritic hyperkeratotic nodules on extremities and trunk. Neuroimmune dysregulation and chronic scratching are believed to both induce and maintain the characteristic lesions.

objectivesThis study sought to provide a comprehensive view of the molecular pathogenesis of PN at the single-cell level to identify and outline key pathologic processes and the cell types involved. Features that distinguish PN skin from the skin of patients with atopic dermatitis were of particular interest. We further aimed to determine the impact of the IL31RA antagonist, nemolizumab, and its specificity at the single-cell level.

methodsSingle-cell RNA-sequencing of skin from 15 healthy donors and nonlesional and lesional skin from 6 patients each with PN and atopic dermatitis, combined with spatial-sequencing using the 10x Visium platform. Integration with bulk RNA-sequencing data from patients treated with nemolizumab.

resultsThis study demonstrates that PN is an inflammatory skin disease characterized by both keratinocyte proliferation and activation of profibrotic responses. This study also demonstrates that the COL11A1

conclusionsThis study provides a high-resolution characterization of the cell types and cellular processes activated in PN skin, establishing PN as a chronic fibrotic inflammatory skin disease. It further demonstrates the broad effect of nemolizumab on pathological processes in PN skin.

Indexed as

Dermatitis, AtopicPrurigoAntibodies, Monoclonal, HumanizedChronic DiseaseHumansPruritusRNASkinAntibodies, Monoclonal, HumanizednemolizumabRNAfibrosisinflammationnemolizumabPrurigo nodularissingle-cell RNA-sequencingspatial-sequencing

Identifiers

PMID37506977
PMCPMC11231883
OpenAlexW4385359506

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.