Evidence map›Paper›PMID 37506952›Full record

ArticleFree radical biology & medicine2023

VHL-deficiency leads to reductive stress in renal cells.

Hans Vellama, Kattri-Liis Eskla, Hillar Eichelmann, Andria Hüva, Daniel A Tennant, Alpesh Thakker, Jennie Roberts, Toomas Jagomäe, Rando Porosk, Agu Laisk and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Reductive stress in cancer immunology and targeted therapy.Acta biochimica et biophysica Sinica · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Hans VellamaInstitute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, Tartu, Estonia; Centre of Excellence for Genomics and Translational Medicine, University of Tartu, Tartu, Estonia.
Kattri-Liis EsklaInstitute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, Tartu, Estonia; Centre of Excellence for Genomics and Translational Medicine, University of Tartu, Tartu, Estonia. Electronic address: kattri-liis.eskla@ut.ee.
Hillar EichelmannInstitute of Biomedicine and Translational Medicine, Department of Pathophysiology, University of Tartu, Tartu, Estonia; Institute of Technology, University of Tartu, Tartu, Estonia.
Andria HüvaInstitute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, Tartu, Estonia.
Daniel A TennantInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Alpesh ThakkerInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Jennie RobertsInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Toomas JagomäeInstitute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, Tartu, Estonia; Centre of Excellence for Genomics and Translational Medicine, University of Tartu, Tartu, Estonia.
Rando PoroskInstitute of Biomedicine and Translational Medicine, Department of Biochemistry, University of Tartu, Tartu, Estonia.
Agu LaiskInstitute of Technology, University of Tartu, Tartu, Estonia.
Vello OjaInstitute of Technology, University of Tartu, Tartu, Estonia.
Heikko RämmaInstitute of Technology, University of Tartu, Tartu, Estonia.
Vallo VolkeInstitute of Biomedicine and Translational Medicine, Department of Pathophysiology, University of Tartu, Tartu, Estonia.
Eero VasarInstitute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, Tartu, Estonia; Centre of Excellence for Genomics and Translational Medicine, University of Tartu, Tartu, Estonia.
Hendrik LuukInstitute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, Tartu, Estonia; Centre of Excellence for Genomics and Translational Medicine, University of Tartu, Tartu, Estonia.
University of Tartu · EEUniversity of Birmingham · GB

Funding

Cancer Research UK 24757Cancer Research UK A24757
6 · The paper itself

Abstract

Heritable renal cancer syndromes (RCS) are associated with numerous chromosomal alterations including inactivating mutations in von Hippel-Lindau (VHL) gene. Here we identify a novel aspect of the phenotype in VHL-deficient human renal cells. We call it reductive stress as it is characterised by increased NADH/NAD

Indexed as

Carcinoma, Renal CellKidney NeoplasmsGlutamineHumansUp-RegulationVon Hippel-Lindau Tumor Suppressor ProteinGlutamineVHL protein, humanVon Hippel-Lindau Tumor Suppressor ProteinHIFReductive stressRenal cell carcinomaRespirationVHLVHL syndrome

Identifiers

PMID37506952
PMCPMC10602395
OpenAlexW4385269616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.