Evidence map›Paper›PMID 37506723›Full record

ReviewThe lancet. HIV2023

Global HIV control: is the glass half empty or half full?

Jean B Nachega, Philippa Musoke, Peter H Kilmarx, Monica Gandhi, Beatriz Grinsztejn, Anton Pozniak, Angeli Rawat, Lindsay Wilson, Edward J Mills, Frederick L Altice and 2 more

Open access · greenAbstract readReview
In one paragraph

Review in The lancet. HIV, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. [Characterization of immune reconstitution inflammatory syndrome in a Mexican cohort].Revista medica del Instituto Mexicano del Seguro Social · 2026
    Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 6 countries.

Jean B NachegaDepartment of Epidemiology, Department of Infectious Diseases, Department of Microbiology, and Center for Global Health, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA; Department of Epidemiology and Department of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University of Baltimore, MD, USA; Department of Medicine, Division of Infectious Diseases, Stellenbosch University Faculty of Medicine and Health Sciences, Cape Town, South Africa. Electronic address: jbn16@pitt.edu.
Philippa MusokeMakerere University-Johns Hopkins University (MUJHU) Research Collaboration, Kampala, Uganda.
Peter H KilmarxFogarty International Center, US National Institutes of Health, Bethesda, MD, USA.
Monica GandhiDepartment of Medicine, Division of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco (UCSF), San Francisco, CA, USA.
Beatriz GrinsztejnInstituto National de Infectologia Evandro Chagas-Fiocruz, Rio de Janeiro, Brazil.
Anton PozniakChelsea and Westminster Hospital National Health Service Foundation Trust, London, UK; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.
Angeli RawatSchool of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
Lindsay WilsonPlatform Life Sciences, Vancouver, BC, Canada.
Edward J MillsPlatform Life Sciences, Vancouver, BC, Canada; Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Frederick L AlticeDepartment of Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.
John W MellorsDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Thomas C QuinnDivision of Infectious Diseases, Johns Hopkins School of Medicine; and Center for Global Health, Johns Hopkins University, Baltimore, MD, USA; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Center for Global Health · USImpact · CAInstituto Evandro Chagas · BRLondon School of Hygiene & Tropical Medicine · GBMUJHU Research Collaboration · UGNational Institutes of Health · USUniversity of Baltimore · USUniversity of British Columbia · CAUniversity of California, San Francisco · USUniversity of Pittsburgh · USYale University · US

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Validation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
University of Pittsburgh Clinical Trials UnitUM1AI069494 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SUSAN L KOLETAR, John W Mellors · 2012 to 2026
$38.0M
"Enhancing Cancer Research in Central Africa IeDEA"U01AI096299 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Denis Nash, Marcel Yotebieng · 2011 to 2026
$35.8M
REACH: Research Enterprise to Advance a Cure for HIVUM1AI164565 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Marina Caskey, R. Brad Jones · 2021 to 2026
$32.9M
I4C 2.0: Immunotherapy for CureUM1AI164556 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Dan H. Barouch, John W Mellors · 2021 to 2026
$28.0M
Combined Immunologic Approaches to Cure HIV-1UM1AI126603 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H., MELLORS, JOHN W · 2016 to 2020
$23.6M
Prison Interventions and HIV Prevention CollaborationR01DA029910 · NIDA · YALE UNIVERSITY · PI FREDERICK LEWIS ALTICE · 2010 to 2026
$7.9M
Expanding Medication Assisted Therapy in Ukraine (ExMAT)R01DA033679 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2012 to 2021
$6.4M
Integrating Addiction and Infectious Diseases Services into Primary Care in Rural SettingsR01DA054703 · NIDA · YALE UNIVERSITY · PI FREDERICK LEWIS ALTICE, JUDITH FEINBERG · 2021 to 2026
$5.7M
Randomized Trial to Optimize Virologic Suppression Rates Using a Point-of-Care Urine Monitoring Assay (ROVING-PUMA)R01AI143340 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2018 to 2026
$5.6M
FIC NIH HHS D43 TW010937FIC NIH HHS D43 TW011324FIC NIH HHS D43 TW011827FIC NIH HHS D43 TW012492FIC NIH HHS R01 TW012674FIC NIH HHS R21 TW011663FIC NIH HHS R21 TW011706FIC NIH HHS R25 TW011217NCATS NIH HHS UL1 TR001863NCI NIH HHS 75N91019D00024NIAID NIH HHS R01 AI143340NIAID NIH HHS R37 AI098472NIAID NIH HHS U01 AI096299NIAID NIH HHS UM1 AI069494NIAID NIH HHS UM1 AI106701NIAID NIH HHS UM1 AI126603NIAID NIH HHS UM1 AI164556NIAID NIH HHS UM1 AI164565NIDA NIH HHS R01 DA029910NIDA NIH HHS R01 DA033679NIDA NIH HHS R01 DA043125NIDA NIH HHS R01 DA045384NIDA NIH HHS R01 DA054703NIDA NIH HHS R01 DA054851NIDA NIH HHS R01 DA059291NIDA NIH HHS R21 DA041953
6 · The paper itself

Abstract

The massive scale-up of HIV treatment and prevention over the past two decades has resulted in important reductions in new infections and mortality globally. Reduction in HIV incidence, however, has been unequal, with worsening epidemics in regions where the reach and scale of HIV control programmes have been insufficient, especially in eastern Europe, central Asia, the Middle East, north Africa, and Latin America where HIV epidemics are concentrated among key populations, including people who inject drugs, men who have sex with men, transgender people, and some minority racial and ethnic groups. The global state of the HIV pandemic highlights disparities in HIV control efforts and provides a roadmap for what should be done, including investment to better implement the effective HIV prevention and treatment tools that are available, but whose adoption and scale-up are not yet sufficient to get us close to an AIDS-free generation. To achieve the full potential of global HIV control, we call for urgent, evidence-informed implementation at scale of our existing and novel HIV prevention and treatment strategies in ways that are better, faster, more efficient, and cost-effective, especially in key populations and regions where the HIV pandemic continues to expand.

Indexed as

Acquired Immunodeficiency SyndromeHIV InfectionsSexual and Gender MinoritiesAfrica, NorthernHomosexuality, MaleHumansMale

Identifiers

PMID37506723
PMCPMC10733629
OpenAlexW4385232088

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.