ArticleCurrent biology : CB2023
Recruitment of grid-like responses in human entorhinal and piriform cortices by odor landmark-based navigation.
Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Olfactory spatial memory: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- No link between piriform cortex subregion resection and seizure freedom in two cohorts with temporal lobe epilepsy.Journal of neurology · 2026Article
- Article
- Tastes and retronasal odours evoke a shared flavour-specific neural code in the human insula.Nature communications · 2025Article
- How do mammals convert dynamic odor information into neural maps for landscape navigation?PLoS biology · 2024Article
- What Does the Human Olfactory System Do, and How Does It Do It?Annual review of psychology · 2024Review
- An experimental framework for conjoint measures of olfaction, navigation, and motion as pre-clinical biomarkers of Alzheimer's disease.Journal of Alzheimer's disease reports · 2024Review
- Leveraging multi-echo EPI to enhance BOLD sensitivity in task-based olfactory fMRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
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5 authors at 2 institutions in 1 country.
Funding
Abstract
Olfactory navigation is universal across the animal kingdom. Humans, however, have rarely been considered in this context. Here, we combined olfactometry techniques, virtual reality (VR) software, and neuroimaging methods to investigate whether humans can navigate an olfactory landscape by learning the spatial relationships among discrete odor cues and integrating this knowledge into a spatial map. Our data show that over time, participants improved their performance on the odor navigation task by taking more direct paths toward targets and completing more trials within a given time period. This suggests that humans can successfully navigate a complex odorous environment, reinforcing the notion of human olfactory navigation. fMRI data collected during the olfactory navigation task revealed the emergence of grid-like responses in entorhinal and piriform cortices that were attuned to the same grid orientation. This result implies the existence of a specialized olfactory grid network tasked with guiding spatial navigation based on odor landmarks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.