ArticleNeurobiology of aging2023
Lower socioeconomic status is associated with premature brain aging.
Article in Neurobiology of aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cardiometabolic risk factors and brain age: a meta-analysis to quantify brain structural differences related to diabetes, hypertension, and obesity.Journal of psychiatry & neuroscience : JPNPooled it
- Neurobiological markers across joint profiles of subjective cognitive decline and objective cognitive function in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- Your brain doesn't look a day past 70! Cross-sectional associations with brain-predicted age in the cognitively-intact oldest-old.GeroScience · 2026Article
- The role of metabolic health in neurostructural and cognitive alterations in bipolar disorders.Psychological medicine · 2026Article
- Synchrony between brain age and internalising and externalising symptoms across adolescence.medRxiv : the preprint server for health sciences · 2026Article
- Brain age gradients as intermediate phenotypes linking plasma p-tau217 to cognition in community-dwelling older adults.NPJ dementia · 2026Article
- Deep learning-based brain age predicts stroke recurrence in acute ischemic cerebrovascular disease.NPJ digital medicine · 2025Article
- Causal association of education attainment with aging and cardiac death: Evidence from Mendelian randomization analysis.Medicine · 2025Article
- Potential vulnerability and resilience to accelerated brain aging in women exposed to stressful life events: insights from the brain age prediction model.Neurobiology of stress · 2025Article
- Sensitive periods for the link between childhood maltreatment and brain aging during adulthood.Neurobiology of stress · 2025Article
- Epigenetic age is associated with regional brain aging along the sensorimotor-to-association axis of cortical organization.Neurobiology of aging · 2025Article
- Current challenges and future directions for brain age prediction in children and adolescents.Nature communications · 2025Review
- Distinct brain age gradients across the adult lifespan reflect diverse neurobiological hierarchies.Communications biology · 2025Article
- A Case for estradiol: younger brains in women with earlier menarche and later menopause.GigaScience · 2025Article
- Assessing the Utility of Predicted Brain Age for Explaining Variability in Language Abilities in Healthy Older Adults.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Mapping computational cognitive profiles of aging to dissociable brain and sociodemographic factors.npj aging · 2024Article
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Authors and funding
14 authors.
Funding
Abstract
backgroundPremature age-related brain changes may be influenced by physical health factors. Lower socioeconomic status (SES) is often associated with poorer physical health. In this study, we aimed to investigate the relationship between SES and premature brain aging.
methodsBrain age was estimated from T1-weighted images using BrainAgeR in 217 participants from the ABC@UofSC Repository. The difference between brain and chronological age (BrainGAP) was calculated. Multiple regression models were used to predict BrainGAP with age, SES, body mass index, diabetes, hypertension, sex, race, and education as predictors. SES was calculated from size-adjusted household income and the cost of living.
resultsFifty-five participants (25.35%) had greater brain age than chronological age (premature brain aging). Multiple regression models revealed that age, sex, and SES were significant predictors of BrainGAP with lower SES associated with greater BrainGAP (premature brain aging).
conclusionsThis study demonstrates that lower SES is an independent contributor to premature brain aging. This may provide additional insight into the mechanisms associated with brain health, cognition, and resilience to neurological injury.
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