Evidence map›Paper›PMID 37506202›Full record

ArticleScience advances2023

Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere.

Tom Dendooven, Ziguo Zhang, Jing Yang, Stephen H McLaughlin, Johannes Schwab, Sjors H W Scheres, Stanislau Yatskevich, David Barford

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
22.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 57 citations in OpenAlex.

  1. Structure and function of the outer kinetochore.Nature reviews. Molecular cell biology · 2026
    Review
  2. An interdependent Cbf1-CCAN interaction stabilizes the budding yeast kinetochore.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
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  6. Article
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  10. Structure and dynamics of 2x(CENP-A/H4)Life science alliance · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Sustainable integrative cell biology: CENP-C is guilty by association.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Article
  16. Article
  17. Article
  18. Centromeres in the thermotolerant yeast K. marxianus mediate attachment to a single microtubule.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tom DendoovenMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0002-9847-0910
Ziguo ZhangMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0002-7268-9631
Jing YangMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0002-8984-4503
Stephen H McLaughlinMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0001-9135-6253
Johannes SchwabMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0002-7144-3031
Sjors H W ScheresMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0002-0462-6540
Stanislau YatskevichMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0003-2999-6561
David BarfordMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0001-8810-950X
MRC Laboratory of Molecular Biology · GB

Funding

Cancer Research UK 14109Cancer Research UK 24307Medical Research Council MC_UP_1201/6Medical Research Council MC_UP_A025_1013Wellcome Trust
6 · The paper itself

Abstract

The point centromere of budding yeast specifies assembly of the large kinetochore complex to mediate chromatid segregation. Kinetochores comprise the centromere-associated inner kinetochore (CCAN) complex and the microtubule-binding outer kinetochore KNL1-MIS12-NDC80 (KMN) network. The budding yeast inner kinetochore also contains the DNA binding centromere-binding factor 1 (CBF1) and CBF3 complexes. We determined the cryo-electron microscopy structure of the yeast inner kinetochore assembled onto the centromere-specific centromere protein A nucleosomes (CENP-A

Indexed as

Saccharomyces cerevisiae ProteinsSaccharomycetalesBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCentromereCentromere Protein AChromosomal Proteins, Non-HistoneCryoelectron MicroscopyDNAKinetochoresNuclear ProteinsProtein SubunitsSaccharomyces cerevisiaeBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCBF1 protein, S cerevisiaeCentromere Protein AChromosomal Proteins, Non-HistoneDNANDC80 protein, S cerevisiaeNuclear ProteinsProtein SubunitsSaccharomyces cerevisiae Proteins

Identifiers

PMID37506202
PMCPMC10381965
OpenAlexW4385334888

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.