Evidence map›Paper›PMID 37505856›Full record

ReviewVeterinary sciences2023

Research Progress on NSP11 of Porcine Reproductive and Respiratory Syndrome Virus.

Yajie Zheng, Hang Zhang, Qin Luo, Huiyang Sha, Gan Li, Xuanru Mu, Yingxin He, Weili Kong, Anfeng Wu, Haoji Zhang and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Veterinary sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Genetic variation and recombination analysis of theFrontiers in veterinary science · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Yajie ZhengSchool of Life Science and Engineering, Foshan University, Foshan 528231, China.
Hang ZhangSchool of Life Science and Engineering, Foshan University, Foshan 528231, China.
Qin LuoSchool of Life Science and Engineering, Foshan University, Foshan 528231, China.
Huiyang ShaSchool of Life Science and Engineering, Foshan University, Foshan 528231, China.
Gan LiSchool of Life Science and Engineering, Foshan University, Foshan 528231, China.
Xuanru MuSchool of Life Science and Engineering, Foshan University, Foshan 528231, China.
Yingxin HeSchool of Life Science and Engineering, Foshan University, Foshan 528231, China.
Weili KongGladstone Institutes of Virology and Immunology, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-9104-7730
Anfeng WuMaccura Biotechnology Co., Ltd., Chengdu 510000, China.
Haoji ZhangSchool of Life Science and Engineering, Foshan University, Foshan 528231, China.
Xingang YuSchool of Life Science and Engineering, Foshan University, Foshan 528231, China.
Foshan University · CNGladstone Institutes · US

Funding

National Natural Science Foundation of China 31902279
6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome (PRRS) is a virulent infectious disease caused by the PRRS virus (PRRSV). The non-structural protein 11 (NSP11) of PRRSV is a nidovirus-specific endonuclease (NendoU), which displays uridine specificity and catalytic functions conserved throughout the entire NendoU family and exerts a wide range of biological effects. This review discusses the genetic evolution of NSP11, its effects on PRRSV replication and virulence, its interaction with other PRRSV and host proteins, its regulation of host immunity, the conserved characteristics of its enzyme activity (NendoU), and its diagnosis, providing an essential theoretical basis for in-depth studies of PRRSV pathogenesis and vaccine design.

Indexed as

enzyme activitygenetic evolutionNSP11porcine reproductive and respiratory syndrome virusprotein interactionsviral replication

Identifiers

PMID37505856
PMCPMC10384725
OpenAlexW4383736806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.