Evidence map›Paper›PMID 37505794›Full record

ArticlePediatric blood & cancer2023

Children's Oncology Group's 2023 blueprint for research: Hodgkin lymphoma.

Sharon M Castellino, Lisa Giulino-Roth, Paul Harker-Murray, Justine M Kahn, Christopher Forlenza, Steve Cho, Bradford Hoppe, Susan K Parsons, Kara M Kelly, COG Hodgkin Lymphoma Committee

Open access · bronzeAbstract read
In one paragraph

Article in Pediatric blood & cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Pediatric lymphomas: overview and diagnostic challenges.Virchows Archiv : an international journal of pathology · 2025
    Review
  8. Review
  9. Pediatric and Adolescent Hodgkin Lymphoma: Paving the Way for Standards of Care and Shared Decision Making.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2024
    Review
  10. Prognostic value of baseline and interim [European journal of nuclear medicine and molecular imaging · 2024
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 1 country.

Sharon M CastellinoAflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta/Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-8367-2002
Lisa Giulino-RothDepartment of Pediatrics, Weill Cornell Medical College, New York, New York, USA.
Paul Harker-MurrayPediatric Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Justine M KahnDivision of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0003-3330-6754
Christopher ForlenzaDepartment of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Steve ChoDepartment of Radiology, University of Wisconsin/University of Wisconsin Carbone Comprehensive Cancer Center, Madison, Wisconsin, USA.
Bradford HoppeDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, Florida, USA.ORCID 0000-0002-2312-5418
Susan K ParsonsDepartment of Medicine, Tufts University School of Medicine/Department of Pediatrics, Reid R. Sacco AYA Cancer Program/Division of Hematology/Oncology, Tufts University School of Medicine/Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA.
Kara M KellyDepartment of Pediatric Oncology, Roswell Park Comprehensive Cancer Center/Department of Pediatrics, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
COG Hodgkin Lymphoma CommitteeAflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta/Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Columbia University Irving Medical Center · USCornell University · USEmory University · USJacksonville College · USMedical College of Wisconsin · USMemorial Sloan Kettering Cancer Center · USRoswell Park Comprehensive Cancer Center · USTufts University · USUniversity of Wisconsin Carbone Cancer Center · US

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
COG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
Children's Oncology Group Statistics &Data Center GrantU10CA098413 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DEVIDAS, MEENAKSHI · 2003 to 2013
$67.5M
NCI NIH HHS P30 CA008748NCI NIH HHS U10 CA098413NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899
6 · The paper itself

Abstract

The goal of therapy in pediatric Hodgkin lymphoma (HL) is to maximize overall survival while minimizing the morbidity of curative therapy. Key findings from recent Children's Oncology Group (COG) trials include: (i) superior event-free survival with the addition of brentuximab vedotin (Bv) in frontline regimens for high-risk disease, (ii) successful reduction in myeloablative regimens with demonstrated safety and efficacy of Bv and checkpoint inhibitor therapy in relapsed disease, and (ii) the potential to select a population that can be salvaged after relapse without receiving a stem cell transplant. The COG HL committee will lead a National cancer Institute National Clinical Trials Network phase 3 trial to evaluate the combination of Bv/nivolumab in early-stage disease. Ongoing advances in technology and blood biomarkers are increasing the ability to deliver biologically driven, personalized treatment for HL.

Indexed as

Hodgkin DiseaseImmunoconjugatesBrentuximab VedotinChildHumansNeoplasm Recurrence, LocalNivolumabProgression-Free SurvivalBrentuximab VedotinImmunoconjugatesNivolumabAYAHodgkin lymphomapediatric

Identifiers

PMID37505794
PMCPMC10660893
OpenAlexW4385330435

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.