ArticleEnvironmental health perspectives2023
Ambient Air Pollution and Risk of Enterotomy, Gastrointestinal Cancer, and All-Cause Mortality among 4,708 Individuals with Inflammatory Bowel Disease: A Prospective Cohort Study.
Article in Environmental health perspectives, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Impact of Pollution on Cancer: A Systematic Review and Meta-Analysis with Focus on Air Pollution.International journal of environmental research and public health · 2026Pooled it
- Pooled it
- Effects of air pollution on the development and progression of digestive diseases: an umbrella review of systematic reviews and meta-analyses.BMC public health · 2025Pooled it
- Exposure to heavy metals and metalloids in PMScientific reports · 2026Observational
- Current status and advances in research on the impact and mechanisms of atmospheric pollutants on gastric cancer: a narrative review.Translational cancer research · 2026Review
- Global burden of inflammatory bowel disease in Group 20 countries, 1990 to 2021: A systematic analysis with projections to 2050.Medicine · 2026Article
- Inflammatory bowel diseases: pathological mechanisms and therapeutic perspectives.Molecular biomedicine · 2026Review
- Association between long-term ambient air pollution and incident inflammatory bowel disease across levels of adherence to a plant-based diet: a prospective cohort study in the UK Biobank.Frontiers in nutrition · 2026Article
- Association of inflammatory bowel disease with cardiovascular disease, and the mediating role of inflammation: a matched-cohort study.Therapeutic advances in gastroenterology · 2026Article
- Accelerometer-measured moderate-to-vigorous physical activity is associated with reduced risk of bowel resection and mortality in inflammatory bowel disease: a prospective cohort study.International journal of surgery (London, England) · 2025Article
- Fine Particulate Matter (PM2.5) Disrupts Intestinal Barrier Function by Inducing Oxidative Stress and PI3K/AKT-Mediated Inflammation in Caco-2 Cells.International journal of molecular sciences · 2025Article
- Ambient Particulate Matter Exposure Impairs Gut Barrier Integrity and Disrupts Goblet Cell Function.Biomedicines · 2025Article
- Dietary glucosamine supplement use and lower surgery risk in individuals with inflammatory bowel disease: a prospective Cohort Study.European journal of nutrition · 2025Article
- Higher Life's Essential 8 score is associated with reduced risk of related surgery and all-cause mortality among 3232 individuals with inflammatory bowel disease in a longitudinal cohort study.International journal of surgery (London, England) · 2025Article
- Composition of plant-based diets and the incidence and prognosis of inflammatory bowel disease: a multinational retrospective cohort study.The Lancet regional health. Europe · 2025Article
- Global and Chinese Burden of Inflammatory Bowel Disease From 1990 to 2021: A Systematic Analysis and Prediction of Disease Burden.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Long-term exposure to air pollution and gastrointestinal disease: findings from a nationwide cohort study in China.BMC public health · 2025Article
- AMPK agonist AICAR ameliorates maternal hepatic lipid metabolism disorder, inflammation, and fibrosis caused by PMScientific reports · 2025Article
- Acute air pollution exposure and gastrointestinal cancer mortality: a case-crossover study in coastal China.Frontiers in public health · 2025Article
- Sex-specific and socioeconomic disparities in the global burden of inflammatory bowel disease in 204 countries, 1990-2021: projections to 2050.Frontiers in immunology · 2025Article
Corrections and comments
- Commented on by
Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies indicated that air pollution plausibly increases the risk of adverse outcomes in inflammatory bowel disease (IBD) via proinflammatory mechanisms. However, there is scant epidemiological data and insufficient prospective evidence assessing associations between ambient air pollution and clinical outcomes of IBD.
objectivesWe aimed to investigate the associations between ambient air pollution and clinical outcomes among individuals with IBD.
methodsLeveraging data from the UK Biobank, we included 4,708 individuals with IBD recruited in the period 2006-2010 in this study. A land use regression model was used to assess annual mean concentrations of ambient air pollutants nitrogen including oxides (
resultsDuring a mean follow-up of 12.0 y, 265 enterotomy events, 124 incident gastrointestinal cancer, and 420 death events were documented among individuals with IBD. We found that each interquartile range (IQR) increase in exposure to
conclusionsAmbient pollution exposure was associated with an increased risk of enterotomy and all-cause mortality among individuals with IBD, highlighting the important role of environmental health in improving the prognosis of IBD. https://doi.org/10.1289/EHP12215.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.