Evidence map›Paper›PMID 37505740›Full record

ArticleToxins2023

Combination of Zearalenone and Deoxynivalenol Induces Apoptosis by Mitochondrial Pathway in Piglet Sertoli Cells: Role of Endoplasmic Reticulum Stress.

Sirao Hai, Jiawen Chen, Li Ma, Chenlong Wang, Chuangjiang Chen, Sajid Ur Rahman, Chang Zhao, Shibin Feng, Jinjie Wu, Xichun Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sirao HaiCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Jiawen ChenCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Li MaCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Chenlong WangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Chuangjiang ChenCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Sajid Ur RahmanCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0002-5969-5463
Chang ZhaoCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0001-8668-0171
Shibin FengCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Jinjie WuCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Xichun WangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0001-5096-3970
Anhui Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zearalenone (ZEA) and deoxynivalenol (DON) are widely found in various feeds, which harms livestock's reproductive health. Both mitochondria and endoplasmic reticulum (ER) can regulate cell apoptosis. This study aimed to explore the regulatory mechanism of endoplasmic reticulum stress (ERS) on ZEA- combined with DON-induced mitochondrial pathway apoptosis in piglet Sertoli cells (SCs). The results showed that ZEA + DON damaged the ultrastructure of the cells, induced apoptosis, decreased mitochondrial membrane potential, promoted the expression of cytochrome c (CytC), and decreased the cell survival rate. Furthermore, ZEA + DON increased the relative mRNA and protein expression of

Indexed as

ZearalenoneAnimalsApoptosisButylaminesCaspase 3Endoplasmic Reticulum StressMaleMitochondriaProto-Oncogene Proteins c-bcl-2RNA, MessengerSertoli CellsSwineTrichothecenesTumor Suppressor Protein p534-phenylbutylamineButylaminesCaspase 3deoxynivalenolProto-Oncogene Proteins c-bcl-2RNA, MessengerTrichothecenesTumor Suppressor Protein p53Zearalenonedeoxynivalenolendoplasmic reticulum stressmitochondrial pathway apoptosispiglet Sertoli cellszearalenone

Identifiers

PMID37505740
PMCPMC10467067
OpenAlexW4385220352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.