Evidence map›Paper›PMID 37505653›Full record

ArticleTropical medicine and infectious disease2023

Influence of Testosterone in Neglected Tropical Diseases: Clinical Aspects in Leprosy and In Vitro Experiments in Leishmaniasis.

Laís Lima de Oliveira Rekowsky, Daniela Teles de Oliveira, Rodrigo Anselmo Cazzaniga, Lucas Sousa Magalhães, Lenise Franco Albuquerque, Jonnia Maria Sherlock Araujo, Martha Débora Lira Tenório, Tiziane Cotta Machado, Michael W Lipscomb, Priscila Lima Dos Santos and 3 more

Open access · goldAbstract read
In one paragraph

Article in Tropical medicine and infectious disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Laís Lima de Oliveira RekowskyLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju 49060676, Brazil.
Daniela Teles de OliveiraLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju 49060676, Brazil.
Rodrigo Anselmo CazzanigaLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju 49060676, Brazil.
Lucas Sousa MagalhãesLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju 49060676, Brazil.ORCID 0000-0002-2169-7463
Lenise Franco AlbuquerqueLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju 49060676, Brazil.
Jonnia Maria Sherlock AraujoLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju 49060676, Brazil.
Martha Débora Lira TenórioLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju 49060676, Brazil.
Tiziane Cotta MachadoLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju 49060676, Brazil.
Michael W LipscombDepartment of Pharmacology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Priscila Lima Dos SantosLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju 49060676, Brazil.
Amelia Ribeiro de JesusLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju 49060676, Brazil.
Márcio Bezerra-SantosLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju 49060676, Brazil.
Ricardo Luís Louzada da SilvaLaboratory of Immunology and Molecular Biology, Federal University of Sergipe, Aracaju 49060676, Brazil.ORCID 0000-0002-5294-1203
Universidade Federal de Sergipe · BRUniversity of Minnesota · US

Funding

National Council for Scientific and Technological Development 421060/2018-2
6 · The paper itself

Abstract

Neglected tropical diseases encompass a group of chronic and debilitating infectious diseases that primarily affect marginalized populations. Among these diseases, leprosy and leishmaniasis are endemic in numerous countries and can result in severe and disfiguring manifestations. Although there have been reports indicating a higher incidence of leprosy and leishmaniasis in males, the underlying factors contributing to this observation remain unclear. Therefore, the objective of this study was to examine both clinical and experimental evidence regarding the role of testosterone in leprosy and leishmaniasis. A prospective clinical study was conducted to compare the clinical forms of leprosy and assess circulating testosterone levels. Additionally, the impact of testosterone on

Indexed as

leishmanialeprosymacrophage suppressionneuroendocrine systemtestosterone

Identifiers

PMID37505653
PMCPMC10385189
OpenAlexW4383736220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.