Evidence map›Paper›PMID 37505628›Full record

ArticleTropical medicine and infectious disease2023

Contact Tracing and Tuberculosis Preventive Therapy for Household Child Contacts of Pulmonary Tuberculosis Patients in the Kyrgyz Republic: How Well Are We Doing?

Meder Kadyrov, Pruthu Thekkur, Evgenia Geliukh, Aelita Sargsyan, Olga Goncharova, Aizat Kulzhabaeva, Asel Kadyrov, Mohammed Khogali, Anthony D Harries, Abdullaat Kadyrov

Open access · goldAbstract read
In one paragraph

Article in Tropical medicine and infectious disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 5 countries.

Meder KadyrovNational Centre of Phthisiology, Ministry of Health, Bishkek 720000, Kyrgyzstan.
Pruthu ThekkurCentre for Operational Research, International Union Against Tuberculosis and Lung Disease, 2 Rue Jean Lantier, 75001 Paris, France.ORCID 0000-0001-5257-5074
Evgenia GeliukhInternational Charitable Foundation "Alliance for Public Health", 01601 Kiev, Ukraine.
Aelita SargsyanTuberculosis Research and Prevention Centre (TBRPC), Yerevan 0014, Armenia.ORCID 0000-0001-9327-1632
Olga GoncharovaNational Centre of Phthisiology, Ministry of Health, Bishkek 720000, Kyrgyzstan.
Aizat KulzhabaevaPublic Foundation KNCV-KG, Bishkek 720000, Kyrgyzstan.
Asel KadyrovPrimary Healthcare Centre #1, Bishkek 720000, Kyrgyzstan.
Mohammed KhogaliInstitute of Public Health (IPH), College of Medicine and health Sciences (CMHS), United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates.
Anthony D HarriesCentre for Operational Research, International Union Against Tuberculosis and Lung Disease, 2 Rue Jean Lantier, 75001 Paris, France.ORCID 0000-0001-6113-9741
Abdullaat KadyrovNational Centre of Phthisiology, Ministry of Health, Bishkek 720000, Kyrgyzstan.
Ministry of Health of Kyrgyzstan · KGAlliance for Public Health · UAInternational Union Against Tuberculosis and Lung Disease · FRUnited Arab Emirates University · AEUniversity of London · GB

Funding

This SORT IT program was funded by USAID and supported by TDR and implementing partners. TDR is able to conduct its work thanks to the commitment and support from a variety of funders. A full list of TDR donors is available at: https://tdr.who.int/about-u NA
6 · The paper itself

Abstract

Early identification, screening and investigation for tuberculosis (TB), and provision of TB preventive therapy (TPT), reduces risk of TB among child household contacts of pulmonary TB patients (index patients). A cohort study was conducted to describe the care cascade and timeliness of contact tracing and TPT initiation among child household contacts (aged < 15 years) of index patients initiated on TB treatment in Bishkek, the Kyrgyz Republic during October 2021-September 2022. In the register, information on the number of child household contacts was available for 153 (18%) of 873 index patients. Of 297 child household contacts identified, data were available for 285, of whom 261 (92%) were screened for TB. More than 50% were screened after 1 month of the index patient initiating TB treatment. TB was diagnosed in 23/285 (9%, 95% CI: 6-13%) children. Of 238 TB-free children, 130 (55%) were eligible for TPT. Of the latter, 64 (49%) were initiated on TPT, of whom 52 (81%) completed TPT. While TPT completion was excellent, there was deficiency in contact identification, timely screening and TPT initiation. Thus, healthcare providers should diligently request and record details of child household contacts, adhere to contact tracing timelines and counsel caregivers regarding TPT.

Indexed as

childhood TBcontact investigationhousehold contact managementisoniazid preventive therapyoperational researchpediatric TBstructured operational research training initiative (SORT IT)

Identifiers

PMID37505628
PMCPMC10386269
OpenAlexW4381663316

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.