Evidence map›Paper›PMID 37505544›Full record

ArticleToxics2023

PTEN Overexpression Alters Autophagy Levels and Slows Sodium Arsenite-Induced Hepatic Stellate Cell Fibrosis.

Fei Huang, Guanxin Ding, Yanjie Yuan, Lijun Zhao, Wenmeng Ding, Shunhua Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Autophagy andFrontiers in cellular and infection microbiology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fei HuangDepartment of Occupational and Environmental Health, College of Public Health, Xinjiang Medical University, No. 567 Shangde North Road, Shuimogou District, Urumqi 830011, China.
Guanxin DingDepartment of Occupational and Environmental Health, College of Public Health, Xinjiang Medical University, No. 567 Shangde North Road, Shuimogou District, Urumqi 830011, China.
Yanjie YuanThe First Division Hospital of Xinjiang Production and Construction Corps, No. 4, Jiankang Road, Aksu City 843000, China.
Lijun ZhaoDepartment of Occupational and Environmental Health, College of Public Health, Xinjiang Medical University, No. 567 Shangde North Road, Shuimogou District, Urumqi 830011, China.
Wenmeng DingDepartment of Occupational and Environmental Health, College of Public Health, Xinjiang Medical University, No. 567 Shangde North Road, Shuimogou District, Urumqi 830011, China.
Shunhua WuORCID 0000-0002-1243-4119
Xinjiang Medical University · CN

Funding

National Natural Science Foundation of China 82160650
6 · The paper itself

Abstract

Exposure to inorganic arsenic remains a global public health problem. The liver is the main target organ, leading to arsenic-induced liver fibrosis. Phosphatase and tensin homology deleted on chromosome ten (PTEN) may participate in arsenic-induced liver fibrosis by regulating autophagy, but the exact mechanisms remain unclear. We established a mouse model of arsenic poisoning through their drinking water and a fibrosis model using the human hepatic stellate cell line LX-2 through NaAsO

Indexed as

autophagyinorganic arsenicliver fibrosisNotch1/Hes1/PTEN

Identifiers

PMID37505544
PMCPMC10386595
OpenAlexW4383068262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.