Evidence map›Paper›PMID 37505238›Full record

ArticleAnalytical and bioanalytical chemistry2023

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) reveals potential lipid markers between infrapatellar fat pad biopsies of osteoarthritis and cartilage defect patients.

Mirella J J Haartmans, Britt S R Claes, Gert B Eijkel, Kaj S Emanuel, Gabrielle J M Tuijthof, Ron M A Heeren, Pieter J Emans, Berta Cillero-Pastor

Open access · hybridAbstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mirella J J HaartmansDivision of Imaging Mass Spectrometry, Maastricht MultiModal Molecular Imaging Institute (M4i), Maastricht University, Maastricht, the Netherlands.
Britt S R ClaesDivision of Imaging Mass Spectrometry, Maastricht MultiModal Molecular Imaging Institute (M4i), Maastricht University, Maastricht, the Netherlands.
Gert B EijkelDivision of Imaging Mass Spectrometry, Maastricht MultiModal Molecular Imaging Institute (M4i), Maastricht University, Maastricht, the Netherlands.
Kaj S EmanuelLaboratory for Experimental Orthopedics, Department of Orthopedic Surgery, Joint Preserving Clinic, CAPHRI Care and Public Health Research Institute, Maastricht University Medical Center+, Maastricht, the Netherlands.
Gabrielle J M TuijthofBiomedical Device Design and Production Technology, Faculty of Engineering Technology, University of Twente, Enschede, the Netherlands.
Ron M A HeerenDivision of Imaging Mass Spectrometry, Maastricht MultiModal Molecular Imaging Institute (M4i), Maastricht University, Maastricht, the Netherlands.
Pieter J EmansLaboratory for Experimental Orthopedics, Department of Orthopedic Surgery, Joint Preserving Clinic, CAPHRI Care and Public Health Research Institute, Maastricht University Medical Center+, Maastricht, the Netherlands.
Berta Cillero-PastorDivision of Imaging Mass Spectrometry, Maastricht MultiModal Molecular Imaging Institute (M4i), Maastricht University, Maastricht, the Netherlands. b.cilleropastor@maastrichtuniversity.nl.
Maastricht University · NLAmsterdam Neuroscience · NLUniversity of Twente · NL

Funding

Dutch Province of Limburg LINK (Limburg INvesteert in haar Kenniseconomie)Dutch Research Council (NWO) STW P15-23Dutch Research Council (NWO) William Hunter Revisited
6 · The paper itself

Abstract

The incidence of osteoarthritis (OA) has been expected to increase due to an aging population, as well as an increased incidence of intra-articular (osteo-) chondral damage. Lipids have already been shown to be involved in the inflammatory process of OA. This study aims at revealing region-specific lipid profiles of the infrapatellar fat pad (IPFP) of OA or cartilage defect patients by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI), which could be used as biomarkers for early OA detection. A higher presence of phospholipids was found in OA patients compared with cartilage defect patients. In addition, a higher abundance of ether-linked phosphatidylethanolamines (PE O-s) containing arachidonic acid was specifically found in OA patients compared with cartilage defect patients. These lipids were mainly found in the connective tissue of the IPFP. Specific lipid species were associated to OA patients compared with cartilage defect patients. PE O-s have been suggested as possible biomarkers for OA. As these were found more abundantly in the connective tissue, the IPFP's intra-tissue heterogeneity might play an important role in biomarker discovery, implying that the amount of fibrous tissue is associated with OA.

Indexed as

Osteoarthritis, KneeAdipose TissueAgedBiomarkersBiopsyCartilageHumansLasersLipidsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationBiomarkersLipidsBiomarkersCartilage regenerationHoffa’s fat padLipidsMass spectrometry imagingTotal knee arthroplasty

Identifiers

PMID37505238
PMCPMC10556153
OpenAlexW4385331296

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.