Evidence map›Paper›PMID 37505188›Full record

ArticleJournal of medicinal chemistry2023

Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent

Vadims Kovada, Chrislaine Withers-Martinez, Raitis Bobrovs, Hele Na Ce Rule, Edgars Liepins, Solveiga Grinberga, Fiona Hackett, Christine R Collins, Agrita Kreicberga, María Belén Jiménez-Díaz and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Frontiers in parasitology · 2026
    Article
  5. Molecular biology of the cell · 2025
    Article
  6. Small Molecule Protease Inhibitors as Model Peptidomimetics.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  7. Review
  8. Peptidic Boronic AcidJournal of medicinal chemistry · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Vadims KovadaLatvian Institute of Organic Synthesis, Riga LV-1006, Latvia.
Chrislaine Withers-MartinezMalaria Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.
Raitis BobrovsLatvian Institute of Organic Synthesis, Riga LV-1006, Latvia.ORCID 0000-0002-0221-8658
Hele Na Ce RuleLatvian Institute of Organic Synthesis, Riga LV-1006, Latvia.
Edgars LiepinsLatvian Institute of Organic Synthesis, Riga LV-1006, Latvia.
Solveiga GrinbergaLatvian Institute of Organic Synthesis, Riga LV-1006, Latvia.
Fiona HackettMalaria Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.
Christine R CollinsMalaria Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.
Agrita KreicbergaLatvian Institute of Organic Synthesis, Riga LV-1006, Latvia.
María Belén Jiménez-DíazThe Art of Discovery SL, Biscay Science and Technology Park, Derio, 48160 Bizkaia, Basque Country, Spain.
Iñigo Angulo-BarturenThe Art of Discovery SL, Biscay Science and Technology Park, Derio, 48160 Bizkaia, Basque Country, Spain.
Dace RasinaLatvian Institute of Organic Synthesis, Riga LV-1006, Latvia.ORCID 0000-0002-7788-7100
Edgars SunaLatvian Institute of Organic Synthesis, Riga LV-1006, Latvia.ORCID 0000-0002-3078-0576
Kristaps JaudzemsLatvian Institute of Organic Synthesis, Riga LV-1006, Latvia.ORCID 0000-0003-3922-2447
Michael J BlackmanMalaria Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.ORCID 0000-0002-7442-3810
Aigars JirgensonsLatvian Institute of Organic Synthesis, Riga LV-1006, Latvia.ORCID 0000-0002-8937-8792
Latvijas Organiskās Sintēzes Institūts · LVThe Francis Crick Institute · GBEuskadiko Parke Teknologikoa · ES

Funding

Wellcome Trust CC2129
6 · The paper itself

Abstract

The

Indexed as

AntimalarialsPeptidomimeticsAnimalsAspartic Acid EndopeptidasesMicePlasmodium falciparumProtease InhibitorsProtozoan ProteinsAntimalarialsAspartic Acid EndopeptidasesPeptidomimeticsplasmepsinProtease InhibitorsProtozoan Proteins

Identifiers

PMID37505188
PMCPMC10424242
OpenAlexW4385330980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.