ArticleRadiology. Imaging cancer2023
A Radiomics Model Based on Synthetic MRI Acquisition for Predicting Neoadjuvant Systemic Treatment Response in Triple-Negative Breast Cancer.
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Article in Radiology. Imaging cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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21citing papers in PubMed, 1 pooled it
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21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- ESR Essentials: artificial intelligence in breast imaging-practice recommendations by the European Society of Breast Imaging.European radiology · 2026Guideline
- Multimodal imaging and artificial intelligence for response assessment to neoadjuvant therapy in breast cancer: a comprehensive review.NPJ breast cancer · 2026Review
- Nano-radiomics of molecular MRI for early amyloid associated patterns in an Alzheimer's disease mouse model via an automatic pipeline.BMC medical imaging · 2026Article
- Multi-regional radiomics of obstructive sleep apnea based on synthetic MRI.Respiratory research · 2026Article
- Histogram analysis of relaxometry from synthetic MRI for differentiation of breast BI-RADS 4 non-mass enhancement lesions.BMC medical imaging · 2025Article
- Imaging- and Tumor Biomarker-Based Multivariable Model for Early Prediction of Pathologic Complete Response to Neoadjuvant Systemic Therapy in Triple-Negative Breast Cancer.JCO precision oncology · 2025Article
- Diagnostic accuracy of a machine learning model using radiomics features from breast synthetic MRI.BMC medical imaging · 2025Article
- Article
- A 20-feature radiomic signature of triple-negative breast cancer identifies patients at high risk of death.NPJ breast cancer · 2025Article
- Technical development and In Silico implementation of SyntheticMR in head and neck adaptive radiation therapy: A prospective R-IDEAL stage 0/1 technology development report.Journal of applied clinical medical physics · 2025Article
- Application of Machine Learning to Breast MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Review
- Theranostic Nanoprobes Assisted NIR-II Fluorescence Imaging for Efficient Angiography and Tumor Therapy.ACS omega · 2025Article
- Technical aspects and clinical applications of synthetic MRI: a scoping review.Diagnosis (Berlin, Germany) · 2025Article
- Longitudinal MRI-Driven Multi-Modality Approach for Predicting Pathological Complete Response and B Cell Infiltration in Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The Role of Synthetic MRI and Radiomics in Breast Cancer: A Review.Advanced biomedical research · 2025Review
- Deep Learning and Radiomics in Triple-Negative Breast Cancer: Predicting Long-Term Prognosis and Clinical Outcomes.Journal of multidisciplinary healthcare · 2025Review
- AI Applications to Breast MRI: Today and Tomorrow.Journal of magnetic resonance imaging : JMRI · 2024Review
- Multiparametric MRI-based radiomic models for early prediction of response to neoadjuvant systemic therapy in triple-negative breast cancer.Scientific reports · 2024Article
- Radiologic imaging biomarkers in triple-negative breast cancer: a literature review about the role of artificial intelligence and the way forward.BJR artificial intelligence · 2024Review
- Using Synthetic MRI and Radiomics to Predict Treatment Response in Triple-Negative Breast Cancer.Radiology. Imaging cancer · 2023Article
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26 authors at 2 institutions in 2 countries.
Ken-Pin HwangFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).ORCID 0000-0002-8196-3794
Nabil A ElshafeeyFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Aikaterini KotrotsouFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Huiqin ChenFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Jong Bum SonFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).ORCID 0000-0003-2548-5895
Medine BogeFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Rania M MohamedFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Abeer H AbdelhafezFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Beatriz E AdradaFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).ORCID 0000-0002-5539-5332
Bikash PanthiFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Jia SunFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Benjamin C MusallFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Shu ZhangFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Rosalind P CandelariaFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Jason B WhiteFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Elizabeth E RavenbergFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Debu TripathyFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Clinton YamFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Jennifer K LittonFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Lei HuoFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Alastair M ThompsonFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).
Peng WeiFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).ORCID 0000-0001-7758-6116
Wei T YangFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).ORCID 0000-0003-2936-2972
Mark D PagelFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).ORCID 0000-0002-8109-3995
Jingfei MaFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).ORCID 0000-0003-2827-8891
Gaiane M RauchFrom the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R., D.T., C.Y.), Clinical Research (J.K.L.), Pathology (L.H.), and Abdominal Imaging (G.M.R.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Division of Surgical Oncology, Baylor College of Medicine, Houston, Tex (A.M.T.).ORCID 0000-0003-2079-5202
The University of Texas MD Anderson Cancer Center · USBaylor College of Medicine · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MDevelopment and Dissemination of Clinical CEST MRI Acquisition and Analysis Methods for Cancer Imaging ApplicationsR01CA231513 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MA, JINGFEI, PAGEL, MARK DAVID · 2019 to 2023
$3.1MNCI NIH HHS P30 CA016672NCI NIH HHS R01 CA231513
Abstract
Purpose To determine if a radiomics model based on quantitative maps acquired with synthetic MRI (SyMRI) is useful for predicting neoadjuvant systemic therapy (NAST) response in triple-negative breast cancer (TNBC). Materials and Methods In this prospective study, 181 women diagnosed with stage I-III TNBC were scanned with a SyMRI sequence at baseline and at midtreatment (after four cycles of NAST), producing T1, T2, and proton density (PD) maps. Histopathologic analysis at surgery was used to determine pathologic complete response (pCR) or non-pCR status. From three-dimensional tumor contours drawn on the three maps, 310 histogram and textural features were extracted, resulting in 930 features per scan. Radiomic features were compared between pCR and non-pCR groups by using Wilcoxon rank sum test. To build a multivariable predictive model, logistic regression with elastic net regularization and cross-validation was performed for texture feature selection using 119 participants (median age, 52 years [range, 26-77 years]). An independent testing cohort of 62 participants (median age, 48 years [range, 23-74 years]) was used to evaluate and compare the models by area under the receiver operating characteristic curve (AUC). Results Univariable analysis identified 15 T1, 10 T2, and 12 PD radiomic features at midtreatment that predicted pCR with an AUC greater than 0.70 in both the training and testing cohorts. Multivariable radiomics models of maps acquired at midtreatment demonstrated superior performance over those acquired at baseline, achieving AUCs as high as 0.78 and 0.72 in the training and testing cohorts, respectively. Conclusion SyMRI-based radiomic features acquired at midtreatment are potentially useful for identifying early NAST responders in TNBC.
Indexed as
Triple Negative Breast NeoplasmsBreastFemaleHumansMagnetic Resonance ImagingMiddle AgedNeoadjuvant TherapyProspective StudiesBreastMR ImagingOutcomes Analysis
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