Evidence map›Paper›PMID 37505094›Full record

ArticleAutophagy2023

Starvation-inactivated MTOR triggers cell migration via a ULK1-SH3PXD2A/TKS5-MMP14 pathway in ovarian carcinoma.

Chiao-Yun Lin, Kai-Yun Wu, Lang-Ming Chi, Yun-Hsin Tang, Huei-Jean Huang, Chyong-Huey Lai, Chi-Neu Tsai, Chia-Lung Tsai

Open access · greenAbstract read
In one paragraph

Article in Autophagy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 17 citations in OpenAlex.

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  9. MMP14-Dependent Activation of TGF-β Signaling Enhances Malignancies via Promoting Necroptosis in Glioblastoma.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chiao-Yun LinGynecologic Cancer Research Center, Chang Gung Memorial Hospital, Taoyuan City, Guishan District, Taiwan.
Kai-Yun WuGynecologic Cancer Research Center, Chang Gung Memorial Hospital, Taoyuan City, Guishan District, Taiwan.
Lang-Ming ChiMolecular Medicine Research Center, Chang Gung University, Taoyuan City, Guishan District, Taiwan.
Yun-Hsin TangGynecologic Cancer Research Center, Chang Gung Memorial Hospital, Taoyuan City, Guishan District, Taiwan.
Huei-Jean HuangGynecologic Cancer Research Center, Chang Gung Memorial Hospital, Taoyuan City, Guishan District, Taiwan.
Chyong-Huey LaiGynecologic Cancer Research Center, Chang Gung Memorial Hospital, Taoyuan City, Guishan District, Taiwan.
Chi-Neu TsaiGraduate Institute of Clinical Medical Science, Chang-Gung University, Taoyuan City, Guishan District, Taiwan.
Chia-Lung TsaiGenomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Taoyuan City, Guishan District, Taiwan.
Chang Gung Memorial Hospital · TWChang Gung University · TWLinkou Chang Gung Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abbreviationsAMPK: AMP-activated protein kinase; CHX: cycloheximide; RAD001: everolimus; HBSS: Hanks' balanced salt solution; LC-MS/MS: liquid chromatography-mass spectrometry/mass spectrometry; MMP14: matrix metallopeptidase 14; MTOR: mechanistic target of rapamycin kinase; MAPK: mitogen-activated protein kinase; RB1CC1/FIP200: RB1 inducible coiled-coil 1; PtdIns3P: phosphatidylinositol-3-phosphate; PX: phox homology; SH3: Src homology 3; SH3PXD2A/TKS5: SH3 and PX domains 2A; SH3PXD2A-[6A]: S112A S142A S146A S147A S175A S348A mutant; ULK1: unc-51 like autophagy activating kinase 1.

Indexed as

AutophagyOvarian NeoplasmsAdaptor Proteins, Vesicular TransportAMP-Activated Protein KinasesAutophagy-Related Protein-1 HomologCell MovementChromatography, LiquidFemaleHumansIntracellular Signaling Peptides and ProteinsMatrix Metalloproteinase 14Tandem Mass SpectrometryTOR Serine-Threonine KinasesAdaptor Proteins, Vesicular TransportAMP-Activated Protein KinasesAutophagy-Related Protein-1 HomologIntracellular Signaling Peptides and ProteinsMatrix Metalloproteinase 14MMP14 protein, humanMTOR protein, humanSH3PXD2A protein, humanTOR Serine-Threonine KinasesULK1 protein, humancellular migrationMMP14ovarian cancerSH3PXD2AULK1

Identifiers

PMID37505094
PMCPMC10621272
OpenAlexW4385330453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.