Evidence map›Paper›PMID 37504573›Full record

ArticleJournal of virology2023

Human astrovirus capsid protein releases a membrane lytic peptide upon trypsin maturation.

Matthew Ykema, Kai Ye, Meng Xun, Justin Harper, Miguel A Betancourt-Solis, Carlos F Arias, James A McNew, Yizhi Jane Tao

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Matthew YkemaDepartment of BioSciences, Rice University , Houston, Texas, USA.ORCID 0000-0002-5995-0663
Kai YeDepartment of BioSciences, Rice University , Houston, Texas, USA.
Meng XunDepartment of BioSciences, Rice University , Houston, Texas, USA.
Justin HarperDepartment of BioSciences, Rice University , Houston, Texas, USA.
Miguel A Betancourt-SolisDepartment of BioSciences, Rice University , Houston, Texas, USA.
Carlos F AriasDepartamento de Genética del Desarrollo y Fisiología Molecular, Universidad Nacional Autónoma de México , Cuernavaca, Morelos, Mexico.ORCID 0000-0003-3130-4501
James A McNewDepartment of BioSciences, Rice University , Houston, Texas, USA.
Yizhi Jane TaoDepartment of BioSciences, Rice University , Houston, Texas, USA.ORCID 0000-0002-0149-2241
Rice University · USUniversidad Nacional Autónoma de México · MX

Funding

HOUSTON AREA MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008280 · NIGMS · RICE UNIVERSITY · PI WENSEL, THEODORE G · 1988 to 2023
$8.0M
Structural, mechanistic, and antigenic insights into the human astrovirus capsidR01AI144090 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI DUBOIS, REBECCA MICHELLE · 2019 to 2023
$2.2M
NIAID NIH HHS R01 AI144090NIGMS NIH HHS T32 GM008280
6 · The paper itself

Abstract

The human astrovirus (HAstV) is a non-enveloped, single-stranded RNA virus that is a common cause of gastroenteritis. Most non-enveloped viruses use membrane disruption to deliver the viral genome into a host cell after virus uptake. The virus-host factors that allow for HAstV cell entry are currently unknown but thought to be associated with the host-protease-mediated viral maturation. Using

Indexed as

Astroviridae InfectionsGastroenteritisMamastrovirusCapsid ProteinsHumansLipidsLiposomesPeptidesPhylogenyTrypsinCapsid ProteinsLipidsLiposomesPeptidesTrypsinastrovirusliposomeproteasesstructural biology

Identifiers

PMID37504573
PMCPMC10506485
OpenAlexW4385331422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.