ArticleCurrent oncology (Toronto, Ont.)2023
An Effective Primary Treatment Using Radiotherapy in Patients with Eyelid Merkel Cell Carcinoma.
Article in Current oncology (Toronto, Ont.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- A single dose of neoadjuvant radiation for Merkel cell carcinoma: Complete pathologic response with minimal morbidity in a rapidly growing lesion of the eye.JAAD case reports · 2025Article
- Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart.Open medicine (Warsaw, Poland) · 2025Article
- Optimizing surgical margins in the treatment of eyelid Merkel cell carcinoma: a tertiary center experience and literature review.Frontiers in ophthalmology · 2025Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMerkel cell carcinoma (MCC) is a rare type of neuroendocrine tumor. Palpebral localization represents 2.5% of MCCs. Surgery is not always possible due to the localization or comorbidities of elderly patients. We hypothesized that radiotherapy (RT) alone could be a curative treatment in patients contraindicated for oncological surgery.
methodsWe performed a retrospective monocentric study of patients with localized eyelid MCC treated with curative intent using curative radiotherapy.
resultsOverall, 11 patients with histologically confirmed eyelid MCC were treated with curative radiotherapy. The median age was 77 years old (range: 53-94). Curative RT was decided mainly due to difficult localization and significant co-morbidities. The median lesion dose was 57 Gy (range: 47-70). Most patients had adjuvant lymph nodes irradiation with a median dose of 50 Gy (
conclusionOur data suggest that curative radiotherapy is an effective and safe treatment for Merkel cell carcinoma of the eyelid and periocular region. Radiotherapy alone allows limiting the aesthetic and functional sequelae in elderly and comorbid patients who are contraindicated for oncological surgery.
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