Evidence map›Paper›PMID 37504228›Full record

ReviewDentistry journal2023

Propolis Controlled Delivery Systems for Oral Therapeutics in Dental Medicine: A Systematic Review.

Andressa da Silva Barboza, Juliana Silva Ribeiro de Andrade, Monika Lamas Ferreira, Carla Lucía David Peña, Juliê Silveira da Costa, André Ricardo Fajardo, Rafael Guerra Lund

Open access · goldAbstract readReview
In one paragraph

Review in Dentistry journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Effectiveness of a nanoemulsion-containingDental research journal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andressa da Silva BarbozaGraduate Program in Dentistry, Pelotas Dental School, Federal University of Pelotas, Gonçalves Chaves Street, 457/Rm 702-3, Downtown Pelotas, Pelotas 96015-560, RS, Brazil.
Juliana Silva Ribeiro de AndradeGraduate Program in Dentistry, Pelotas Dental School, Federal University of Pelotas, Gonçalves Chaves Street, 457/Rm 702-3, Downtown Pelotas, Pelotas 96015-560, RS, Brazil.
Monika Lamas FerreiraGraduate Program in Dentistry, Pelotas Dental School, Federal University of Pelotas, Gonçalves Chaves Street, 457/Rm 702-3, Downtown Pelotas, Pelotas 96015-560, RS, Brazil.
Carla Lucía David PeñaGraduate Program in Dentistry, Pelotas Dental School, Federal University of Pelotas, Gonçalves Chaves Street, 457/Rm 702-3, Downtown Pelotas, Pelotas 96015-560, RS, Brazil.
Juliê Silveira da CostaLaboratory of Technology and Development of Composites and Polymeric Materials (LaCoPol), Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, UFPel, Campus Capão do Leão, Pelotas 96010-900, RS, Brazil.
André Ricardo FajardoLaboratory of Technology and Development of Composites and Polymeric Materials (LaCoPol), Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, UFPel, Campus Capão do Leão, Pelotas 96010-900, RS, Brazil.
Rafael Guerra LundGraduate Program in Dentistry, Pelotas Dental School, Federal University of Pelotas, Gonçalves Chaves Street, 457/Rm 702-3, Downtown Pelotas, Pelotas 96015-560, RS, Brazil.
Universidade Federal de Pelotas · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior Finance Code: 001National Council for Scientific and Technological Development [grant number 309848/2017-2]
6 · The paper itself

Abstract

This systematic review synthesizes the existing evidence in the literature regarding the association of propolis with controlled delivery systems (DDSs) and its potential therapeutic action in dental medicine. Two independent reviewers performed a literature search up to 1 June 2023 in five databases: PubMed/Medline, Web of Science, Cochrane Library, Scopus, and Embase, to identify the eligible studies. Clinical, in situ, and in vitro studies that investigated the incorporation of propolis as the main agent in DDSs for dental medicine were included in this study. Review articles, clinical cases, theses, dissertations, conference abstracts, and studies that had no application in dentistry were excluded. A total of 2019 records were initially identified. After carefully examining 21 full-text articles, 12 in vitro studies, 4 clinical, 1 animal model, and 3 in vivo and in vitro studies were included (n = 21). Relevant data were extracted from the included studies and analyzed qualitatively. The use of propolis has been reported in cariology, endodontics, periodontics, stomatology, and dental implants. Propolis has shown non-cytotoxic, osteoinductive, antimicrobial, and anti-inflammatory properties. Moreover, propolis can be released from DDS for prolonged periods, presenting biocompatibility, safety, and potential advantage for applications in dental medicine.

Indexed as

drug deliveryguided tissue regenerationoral bone regenerationpropolissystematic reviewtissue engineering

Identifiers

PMID37504228
PMCPMC10378523
OpenAlexW4382812474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.