Evidence map›Paper›PMID 37504142›Full record

ReviewBiosensors2023

Application of Paper-Based Microfluidic Analytical Devices (µPAD) in Forensic and Clinical Toxicology: A Review.

Giacomo Musile, Cristian Grazioli, Stefano Fornasaro, Nicolò Dossi, Elio Franco De Palo, Franco Tagliaro, Federica Bortolotti

Open access · goldAbstract readReview
In one paragraph

Review in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 41 citations in OpenAlex.

  1. Interpol review of forensic drug chemistry, 2022-2025.Forensic science international. Synergy · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Giacomo MusileUnit of Forensic Medicine, Department of Diagnostics and Public Health, University of Verona, P.le Scuro 10, 37134 Verona, Italy.ORCID 0000-0002-6934-4333
Cristian GrazioliDepartment of Agrifood, Environmental and Animal Science, University of Udine, Via Cotonificio 108, 33100 Udine, Italy.
Stefano FornasaroDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgeri 1, 34127 Trieste, Italy.ORCID 0000-0003-3057-7559
Nicolò DossiDepartment of Agrifood, Environmental and Animal Science, University of Udine, Via Cotonificio 108, 33100 Udine, Italy.
Elio Franco De PaloUnit of Forensic Medicine, Department of Diagnostics and Public Health, University of Verona, P.le Scuro 10, 37134 Verona, Italy.
Franco TagliaroUnit of Forensic Medicine, Department of Diagnostics and Public Health, University of Verona, P.le Scuro 10, 37134 Verona, Italy.
Federica BortolottiUnit of Forensic Medicine, Department of Diagnostics and Public Health, University of Verona, P.le Scuro 10, 37134 Verona, Italy.
University of Verona · ITUniversity of Udine · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The need for providing rapid and, possibly, on-the-spot analytical results in the case of intoxication has prompted researchers to develop rapid, sensitive, and cost-effective methods and analytical devices suitable for use in nonspecialized laboratories and at the point of need (PON). In recent years, the technology of paper-based microfluidic analytical devices (μPADs) has undergone rapid development and now provides a feasible, low-cost alternative to traditional rapid tests for detecting harmful compounds. In fact, µPADs have been developed to detect toxic molecules (arsenic, cyanide, ethanol, and nitrite), drugs, and drugs of abuse (benzodiazepines, cathinones, cocaine, fentanyl, ketamine, MDMA, morphine, synthetic cannabinoids, tetrahydrocannabinol, and xylazine), and also psychoactive substances used for drug-facilitated crimes (flunitrazepam, gamma-hydroxybutyric acid (GHB), ketamine, metamizole, midazolam, and scopolamine). The present report critically evaluates the recent developments in paper-based devices, particularly in detection methods, and how these new analytical tools have been tested in forensic and clinical toxicology, also including future perspectives on their application, such as multisensing paper-based devices, microfluidic paper-based separation, and wearable paper-based sensors.

Indexed as

CocaineKetamineForensic ToxicologyLab-On-A-Chip DevicesMicrofluidicsCocaineKetaminebiosensorclinical toxicologydrug-facilitated crimes (DFCs)drug-facilitated sexual assault (DFSA)drugsforensic toxicologyillicit drugsmicrofluidicspaper-based devicespoint-of-need (PON) devicestoxicant

Identifiers

PMID37504142
PMCPMC10377625
OpenAlexW4384823500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.