Evidence map›Paper›PMID 37504135›Full record

ArticleBiosensors2023

Microfluidic-Assisted Synthesis of Metal-Organic Framework -Alginate Micro-Particles for Sustained Drug Delivery.

Akhilesh Bendre, Vinayak Hegde, Kanalli V Ajeya, Subrahmanya Thagare Manjunatha, Derangula Somasekhara, Varalakshmi K Nadumane, Krishna Kant, Ho-Young Jung, Wei-Song Hung, Mahaveer D Kurkuri

Abstract read
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In one paragraph

Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Akhilesh BendreCentre for Research in Functional Materials (CRFM), JAIN (Deemed-to-be University), Jain Global Campus, Bengaluru 562112, Karnataka, India.
Vinayak HegdeCentre for Research in Functional Materials (CRFM), JAIN (Deemed-to-be University), Jain Global Campus, Bengaluru 562112, Karnataka, India.
Kanalli V AjeyaDepartment of Environment and Energy Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea.
Subrahmanya Thagare ManjunathaAdvanced Membrane Materials Research Center, Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
Derangula SomasekharaDepartment of Biotechnology, JAIN (Deemed-to-be-University), School of Sciences, JC Road, 34, 1st Cross Road, Sudharna Nagar, Bengaluru 560027, Karnataka, India.
Varalakshmi K NadumaneDepartment of Biotechnology, JAIN (Deemed-to-be-University), School of Sciences, JC Road, 34, 1st Cross Road, Sudharna Nagar, Bengaluru 560027, Karnataka, India.
Krishna KantBiomedical Research Center (CINBIO), University of Vigo, 36310 Vigo, Spain.ORCID 0000-0003-2948-9471
Ho-Young JungDepartment of Environment and Energy Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea.
Wei-Song HungAdvanced Membrane Materials Research Center, Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
Mahaveer D KurkuriCentre for Research in Functional Materials (CRFM), JAIN (Deemed-to-be University), Jain Global Campus, Bengaluru 562112, Karnataka, India.ORCID 0000-0003-0284-7259

Funding

Department of Science & Technology DST/BDTD/EAG/2019Department of Science & Technology DST/TDT/DDP-31/2021European Commission Marie Sklodowska-Curie grant agreement no. (894227).Vision Group on Science and Technology VGST/K-FISTL1/GRD No. 1053/2021-22
6 · The paper itself

Abstract

Drug delivery systems (DDS) are continuously being explored since humans are facing more numerous complicated diseases than ever before. These systems can preserve the drug's functionality and improve its efficacy until the drug is delivered to a specific site within the body. One of the least used materials for this purpose are metal-organic frameworks (MOFs). MOFs possess many properties, including their high surface area and the possibility for the addition of functional surface moieties, that make them ideal drug delivery vehicles. Such properties can be further improved by combining different materials (such as metals or ligands) and utilizing various synthesis techniques. In this work, the microfluidic technique is used to synthesize Zeolitic Imidazole Framework-67 (ZIF-67) containing cobalt ions as well as its bimetallic variant with cobalt and zinc as ZnZIF-67 to be subsequently loaded with diclofenac sodium and incorporated into sodium alginate beads for sustained drug delivery. This study shows the utilization of a microfluidic approach to synthesize MOF variants. Furthermore, these MOFs were incorporated into a biopolymer (sodium alginate) to produce a reliable DDS which can perform sustained drug releases for up to 6 days (for 90% of the full amount released), whereas MOFs without the biopolymer showed sudden release within the first day.

Indexed as

Metal-Organic FrameworksAlginatesDiclofenacDrug Delivery SystemsHumansMicrofluidicsAlginatesDiclofenacMetal-Organic Frameworksadsorptiondrug deliverymicrofluidic chipMOFssodium alginate

Identifiers

PMID37504135
PMCPMC10377693

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.