Evidence map›Paper›PMID 37504132›Full record

ArticleBiosensors2023

Specific Fluorescent Probes for Imaging DNA in Cell-Free Solution and in Mitochondria in Living Cells.

Anna S Efimova, Mariya A Ustimova, Nelly S Chmelyuk, Maxim A Abakumov, Yury V Fedorov, Olga A Fedorova

Abstract read
In one paragraph

Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna S EfimovaLaboratory of Photoactive Supramolecular Systems, A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova Str. 28, 119334 Moscow, Russia.
Mariya A UstimovaLaboratory of Photoactive Supramolecular Systems, A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova Str. 28, 119334 Moscow, Russia.ORCID 0000-0002-9486-594X
Nelly S ChmelyukDepartment of Medical Nanobiotechnoilogy, Pirogov Russian National Research Medical University, Ostrovityanova Str. 1, 117997 Moscow, Russia.ORCID 0000-0002-2434-2465
Maxim A AbakumovDepartment of Medical Nanobiotechnoilogy, Pirogov Russian National Research Medical University, Ostrovityanova Str. 1, 117997 Moscow, Russia.ORCID 0000-0003-2622-9201
Yury V FedorovLaboratory of Photoactive Supramolecular Systems, A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova Str. 28, 119334 Moscow, Russia.
Olga A FedorovaLaboratory of Photoactive Supramolecular Systems, A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova Str. 28, 119334 Moscow, Russia.

Funding

Russian Science Foundation 21-73-20158
6 · The paper itself

Abstract

New styryl dyes consisting of N-methylpyridine or N-methylquinoline scaffolds were synthesized, and their binding affinities for DNA in cell-free solution were studied. The replacement of heterocyclic residue from the pyridine to quinoline group as well as variation in the phenyl part strongly influenced their binding modes, binding affinities, and spectroscopic responses. Biological experiments showed the low toxicity of the obtained dyes and their applicability as selective dyes for mitochondria in living cells.

Indexed as

DNAFluorescent DyesHeLa CellsHumansMicroscopy, FluorescenceMitochondriaDNAFluorescent DyesDNA bindingfluorescence probemitochondrial selectivitystyryl dyes

Identifiers

PMID37504132
PMCPMC10377282

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.