Evidence map›Paper›PMID 37503820›Full record

ArticleClinical cardiology2023

Increased small extracellular vesicle levels and decreased miR-126 levels associated with atrial fibrillation and coexisting diabetes mellitus.

Panjaree Siwaponanan, Pontawee Kaewkumdee, Payalak Sudcharee, Suthipol Udompunturak, Nusara Chomanee, Kamol Udol, Kovit Pattanapanyasat, Rungroj Krittayaphong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Panjaree SiwaponananResearch Department, Siriraj Center of Research Excellence in Microparticles and Exosomes in Disease, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Pontawee KaewkumdeeDepartment of Medicine, Division of Cardiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Payalak SudchareeResearch Department, Siriraj Center of Research Excellence in Microparticles and Exosomes in Disease, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Suthipol UdompunturakResearch Department, Research Group and Research Network Division, Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok, Thailand.
Nusara ChomaneeDepartment of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Kamol UdolDepartment of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Kovit PattanapanyasatResearch Department, Siriraj Center of Research Excellence in Microparticles and Exosomes in Disease, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Rungroj KrittayaphongDepartment of Medicine, Division of Cardiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.ORCID http://orcid.org/0000-0001-8684-2361
Siriraj Hospital · TH

Funding

Basic Research Fund Mahidol University R016441004Siriraj Research Fund of the Faculty of Medicine Siriraj Hospital, Mahidol University R016233027
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is the most prevalent cardiac arrhythmia. Diabetes mellitus (DM) is one of the risk factors for the development of stroke and thromboembolism in patients with AF. Early identification may reduce the incidence of complications and mortality in AF patients. HYPOTHESIS: AF patients with DM have different pattern of small extracellular vesicle (sEV) levels and sEV-derived microRNA (miRNA) expression compared with those without DM.

methodsWe compared sEV levels and sEV-miRNA expression in plasma from AF patients with and without DM using nanoparticle tracking analysis and droplet digital polymerase chain reaction, respectively.

resultsWe observed a significant increase in total sEV levels (p = .004) and a significant decrease in sEV-miR-126 level (p = .004) in AF patients with DM. Multivariate logistic regression analysis revealed a positive association between total sEV levels and AF with DM (p = .019), and a negative association between sEV-miR-126 level and AF with DM (p = .031). The combination of clinical data, total sEVs, and sEV-miR-126 level had an area under the curve of 0.968 (p < .0001) for discriminating AF with DM, which was shown to be significantly better than clinical data analysis alone (p = .0368).

conclusionsThese results suggest that an increased level of total sEV and a decreased sEV-miR-126 level may play a potential role in the pathophysiology and complications of AF with DM, especially endothelial dysfunction, and can be considered as an applied biomarker for distinguishing between AF with and without DM.

Indexed as

Atrial FibrillationDiabetes MellitusMicroRNAsStrokeHumansRisk FactorsMicroRNAsMIRN126 microRNA, humanatrial fibrillationdiabetes mellitusmicroRNAssmall extracellular vesicles

Identifiers

PMID37503820
PMCPMC10642338
OpenAlexW4385330422

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.