Evidence map›Paper›PMID 37503357›Full record

ArticleEuropean heart journal open2023

Septal radioablation therapy for patients with hypertrophic obstructive cardiomyopathy: first-in-human study.

Xuping Li, Zhaowei Zhu, Jun Liu, Yawen Gao, Yichao Xiao, Zhenfei Fang, Qiming Liu, Xianling Liu, Chunhong Hu, Fang Ma and 8 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04686487 (Stereotactic Ablative Radiotherapy in Patients With Hypertrophic Obstructive Cardiomyopathy), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04686487 nacompletednot on this map

Stereotactic Ablative Radiotherapy in Patients With Hypertrophic Obstructive Cardiomyopathy: First in Man Pilot Study

TypeinterventionalSponsorSecond Xiangya Hospital of Central South UniversityRan2021 to 2022Enrolled5ConditionsHypertrophic Obstructive CardiomyopathyArmsstereotactic ablative radiotherapy
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Application of stereotactic radiotherapy in the treatment of cardiovascular diseases through sympathectomy.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  2. Article
  3. Review
  4. Review
  5. When radiation meets the heart: Future of stereotactic body radiation therapy for hypertrophic obstructive cardiomyopathy.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Xuping LiDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, 139 Mid-Renmin Road, Changsha, Hunan 410011, China.
Zhaowei ZhuDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, 139 Mid-Renmin Road, Changsha, Hunan 410011, China.
Jun LiuRadiology Department, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yawen GaoOncology Department, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yichao XiaoDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, 139 Mid-Renmin Road, Changsha, Hunan 410011, China.
Zhenfei FangDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, 139 Mid-Renmin Road, Changsha, Hunan 410011, China.
Qiming LiuDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, 139 Mid-Renmin Road, Changsha, Hunan 410011, China.
Xianling LiuOncology Department, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chunhong HuOncology Department, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Fang MaOncology Department, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Mu ZengRadiology Department, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhi LiuAnesthesiology Department, Hunan Provincial People's Hospital, Changsha, Hunan, China.
Lin HuDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, 139 Mid-Renmin Road, Changsha, Hunan 410011, China.
Na LiuDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, 139 Mid-Renmin Road, Changsha, Hunan 410011, China.
Fan XiangDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, 139 Mid-Renmin Road, Changsha, Hunan 410011, China.
Xinqun HuDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, 139 Mid-Renmin Road, Changsha, Hunan 410011, China.
Lihong HuangZhongshan Hospital Affiliated to Fudan University, Shanghai, China.
Shenghua ZhouDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, 139 Mid-Renmin Road, Changsha, Hunan 410011, China.ORCID https://orcid.org/0000-0001-5388-7766
Central South University · CNFudan University · CNHunan Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: There is still no non-invasive septal reduction therapy for patients with hypertrophic obstructive cardiomyopathy (HOCM). This study aimed to investigate the feasibility, safety, and efficacy of stereotactic body radiotherapy (SBRT) in patients with drug-refractory symptomatic HOCM. Methods and results: The radiation target of ventricular septum was determined by multiple anatomical imaging. Stereotactic body radiotherapy was performed with standard techniques. Patients were treated with a single fraction of 25 Gy, followed up at 1, 3, 6, and 12 months by clinical visit. Five patients were enrolled and completed the 12 months follow-up. The mean radioablation time was 21.6 min, and the mean target volume was 10.5 cm Conclusion: The current study suggests that SBRT might be a feasible radioablation therapeutic option for patients with drug-refractory symptomatic HOCM. Trial registration: ClinicalTrials.gov Identifier: NCT04686487.

Indexed as

Cardiac fibrosisHypertrophic obstructive cardiomyopathyLeft ventricular outflow tractStereotactic body radiotherapy

Identifiers

PMID37503357
PMCPMC10371052
OpenAlexW4377861544

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.