Evidence map›Paper›PMID 37503288›Full record

ArticleResearch square2023

Low-cost augmented reality goggles enable precision fluorescence-guided cancer surgery.

Leonid Shmuylovich, Christine M O'Brien, Karen Nwosu, Samuel Achilefu

Abstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Leonid ShmuylovichBiophotonics Research Center, Department of Radiology, Washington University in Saint Louis School of Medicine, Saint Louis, MO.
Christine M O'BrienBiophotonics Research Center, Department of Radiology, Washington University in Saint Louis School of Medicine, Saint Louis, MO.
Karen NwosuBiophotonics Research Center, Department of Radiology, Washington University in Saint Louis School of Medicine, Saint Louis, MO.
Samuel AchilefuBiophotonics Research Center, Department of Radiology, Washington University in Saint Louis School of Medicine, Saint Louis, MO.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Training OPportunities in Translational Imaging Education and Research (TOP-TIER)T32EB021955 · NIBIB · WASHINGTON UNIVERSITY · PI Hongyu An, Joseph Edward Ippolito · 2017 to 2026
$2.4M
Imaging Goggles for Fluorescence-Guided SurgeryR01EB030987 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL, BURAS, WILLIAM ROBINSON · 2021 to 2024
$2.1M
IVIS Spectrum CT Preclinical In Vivo Imaging SystemS10OD027042 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2019 to 2019
$599k
NCI NIH HHS P30 CA091842NIBIB NIH HHS R01 EB030987NIBIB NIH HHS T32 EB021955NIH HHS S10 OD027042
6 · The paper itself

Abstract

Disparities in surgical outcomes often result from subjective than objective decisions dictated by surgical training, experience, and available resources. To improve outcomes, surgeons have adopted advancements in robotics, endoscopy, and intra-operative imaging including fluorescence-guided surgery (FGS), which highlight tumors in real-time without using ionizing radiation. However, like many medical innovations, technical, economic, and logistic challenges have hindered widespread adoption of FGS beyond high-resource centers. To overcome these impediments, we developed the fully-wearable and battery-powered fluorescence imaging augmented reality Raspberry Pi-based goggle system (FAR-Pi). Novel device design ensures distance-independent coalignment between real and augmented FAR-Pi views and offers higher spatial resolution, depth of focus, and fluorescence detection sensitivity than existing bulkier, pricier, and wall-powered technologies. When paired with pan-tumor targeting fluorescent agents such as LS301, FAR-Pi objectively identifies tumors in vivo. As an open-source, affordable, and adaptable system, FAR-Pi is poised to democratize access to FGS and improve health outcomes worldwide.

Indexed as

augmented realityFluorescence guided surgeryopen source hardwareRaspberry Piwearable

Identifiers

PMID37503288
PMCPMC10371110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.