Evidence map›Paper›PMID 37503264›Full record

ArticlebioRxiv : the preprint server for biology2023

Sex-Specific Effects of Anxiety on Cognition and Activity-Dependent Neural Networks: Insights from (Female) Mice and (Wo)Men.

Holly C Hunsberger, Seonjoo Lee, Michelle Jin, Marcos Lanio, Alicia Whye, Jiook Cha, Miranda Scarlata, Keerthana Jayaseelan, Christine A Denny

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Holly C HunsbergerDivision of Systems Neuroscience, Research Foundation for Mental Hygiene, Inc. (RFMH) / New York State Psychiatric Institute (NYSPI), New York, NY, USA.
Seonjoo LeeDepartment of Psychiatry, Columbia University Irving Medical Center (CUIMC); New York, NY, USA.
Michelle JinNeurobiology and Behavior (NB&B) Graduate Program, Columbia University, New York, NY, USA.
Marcos LanioNeurobiology and Behavior (NB&B) Graduate Program, Columbia University, New York, NY, USA.
Alicia WhyeDepartment of Psychiatry, Columbia University Irving Medical Center (CUIMC); New York, NY, USA.
Jiook ChaDepartment of Biostatistics (in Psychiatry), Mailman School of Public Health, Columbia University; New York, NY, USA.
Miranda ScarlataDepartment of Neuroscience, Vassar College; Poughkeepsie, NY USA.
Keerthana JayaseelanBarnard College, Columbia University; New York, NY, USA.
Christine A DennyDivision of Systems Neuroscience, Research Foundation for Mental Hygiene, Inc. (RFMH) / New York State Psychiatric Institute (NYSPI), New York, NY, USA.
Columbia University Irving Medical Center · USRosalind Franklin University of Medicine and Science · USSeoul National University of Science and Technology · KRVassar College · USWestchester Medical Center · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Translational Neuroscience Training Grant.T32MH015174 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DENNY, CHRISTINE ANN · 1985 to 2020
$4.0M
Single-cell and target-specific resolution of multiple memories across the brainR01HD101402 · NICHD · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DENNY, CHRISTINE ANN, RAMIREZ, STEVE · 2019 to 2023
$3.8M
Collaboratory on Research Definitions for Cognitive Reserve and ResilienceR24AG061421 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STERN, YAAKOV · 2018 to 2020
$2.5M
Optogenetic dissection of hippocampal circuitry underlying Alzheimers diseaseDP5OD017908 · OD · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DENNY, CHRISTINE ANN · 2013 to 2017
$2.0M
The sex specific impact of anxiety on Alzheimer's disease progressionR00AG059953 · NIA · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI HUNSBERGER, HOLLY CHRISTIAN · 2022 to 2024
$747k
Identification and manipulation of the neural ensembles mediating sundowning in an Alzheimer's disease mouse modelR21AG064774 · NIA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DENNY, CHRISTINE ANN · 2019 to 2020
$446k
Identification and manipulation of whole-brain memory traces following age-related cognitive decline or Alzheimer's diseaseR56AG058661 · NIA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DENNY, CHRISTINE ANN · 2019 to 2019
$405k
The sex specific impact of anxiety on Alzheimer's disease progressionK99AG059953 · NIA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI HUNSBERGER, HOLLY CHRISTIAN · 2019 to 2021
$392k
NIA NIH HHS K99 AG059953NIA NIH HHS R00 AG059953NIA NIH HHS R21 AG064774NIA NIH HHS R24 AG061421NIA NIH HHS R56 AG058661NIA NIH HHS U01 AG024904NICHD NIH HHS R01 HD101402NIH HHS DP5 OD017908NIMH NIH HHS T32 MH015174
6 · The paper itself

Abstract

introductionNeuropsychiatric symptoms (NPS), such as depression and anxiety, are observed in 90% of Alzheimer's disease (AD) patients, two-thirds of whom are women. NPS usually manifest long before AD onset creating a therapeutic opportunity. Here, we examined the impact of anxiety on AD progression and the underlying brain-wide neuronal mechanisms.

methodsTo gain mechanistic insight into how anxiety impacts AD progression, we performed a cross-sectional analysis on mood, cognition, and neural activity utilizing the ArcCreER

resultsFemale AD mice exhibited anxiety-like behavior and cognitive decline at an earlier age than control (Ctrl) mice and male mice. Brain-wide analysis of c-Fos

conclusionsWhile future studies are needed to understand whether anxiety is a predictor, a neuropsychiatric biomarker, or a comorbid symptom that occurs during disease onset, these results suggest that AD network dysfunction is sexually dimorphic, and that personalized medicine may benefit male and female AD patients rather than a one size fits all approach.

Indexed as

Arcengramshippocampusimmediate early genememorysex differences

Identifiers

PMID37503264
PMCPMC10369916
OpenAlexW4384069592

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.