Evidence map›Paper›PMID 37503251›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Covid-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study.

Azzurra Invernizzi, Stefano Renzetti, Christoph van Thriel, Elza Rechtman, Alessandra Patrono, Claudia Ambrosi, Lorella Mascaro, Giuseppa Cagna, Roberto Gasparotti, Abraham Reichenberg and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Azzurra InvernizziDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stefano RenzettiDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Christoph van ThrielLeibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany.
Elza RechtmanDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alessandra PatronoDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Claudia AmbrosiDepartment of Neuroscience, Neuroradiology Unit, ASST Cremona.
Lorella MascaroASST Spedali Civili Hospital, Brescia, Italy.
Giuseppa CagnaDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Roberto GasparottiDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Abraham ReichenbergDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Cheuk Y TangDepartment of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Roberto G LucchiniDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Robert O WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Donatella PlacidiDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Megan K HortonDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Icahn School of Medicine at Mount Sinai · USUniversity of Brescia · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITFlorida International University · USIstituti Ospitalieri di Cremona · ITTU Dortmund University · DE

Funding

The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Maria Jose Rosa · 2014 to 2026
$21.3M
Stress, Lead, Iron Deficiency and NeurodevelopmentR01ES013744 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2007 to 2026
$13.4M
Neurologic function in children exposed to ambient manganeseR01ES019222 · NIEHS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Megan K Horton · 2010 to 2026
$9.1M
NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES013744NIEHS NIH HHS R01 ES019222
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) has been associated with brain functional, structural, and cognitive changes that persist months after infection. Most studies of the neurologic outcomes related to COVID-19 focus on severe infection and aging populations. Here, we investigated the neural activities underlying COVID-19 related outcomes in a case-control study of mildly infected youth enrolled in a longitudinal study in Lombardy, Italy, a global hotspot of COVID-19. All participants (13 cases, 27 controls, mean age 24 years) completed resting state functional (fMRI), structural MRI, cognitive assessments (CANTAB spatial working memory) at baseline (pre-COVID) and follow-up (post-COVID). Using graph theory eigenvector centrality (EC) and data-driven statistical methods, we examined differences in EC

Indexed as

CANTABCOVID-19eigenvector centralitygraph theorymultimodal imagingresting-state fMRIspatial working memorystructural MRI

Identifiers

PMID37503251
PMCPMC10371098
OpenAlexW4385163478

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.