Evidence map›Paper›PMID 37503218›Full record

ArticlebioRxiv : the preprint server for biology2023

Gene-by-environment interactions influence the fitness cost of gene copy-number variation in yeast.

DeElegant Robinson, Elena Vanacloig-Pedros, Ruoyi Cai, Michael Place, James Hose, Audrey P Gasch

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

DeElegant RobinsonCenter for Genomic Science Innovation, University of Wisconsin-Madison, Madison WI 53704.
Elena Vanacloig-PedrosCenter for Genomic Science Innovation, University of Wisconsin-Madison, Madison WI 53704.
Ruoyi CaiCenter for Genomic Science Innovation, University of Wisconsin-Madison, Madison WI 53704.
Michael PlaceCenter for Genomic Science Innovation, University of Wisconsin-Madison, Madison WI 53704.
James HoseCenter for Genomic Science Innovation, University of Wisconsin-Madison, Madison WI 53704.
Audrey P GaschCenter for Genomic Science Innovation, University of Wisconsin-Madison, Madison WI 53704.
University of Wisconsin–Madison · US

Funding

Dissecting the influence of genetic background on aneuploidy tolerance in the model eukaryote Saccharomyces cerevisiaeR01GM147271 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI GASCH, AUDREY · 2022 to 2025
$1.2M
NIGMS NIH HHS R01 GM147271
6 · The paper itself

Abstract

Variation in gene copy number can alter gene expression and influence downstream phenotypes; thus copy-number variation (CNV) provides a route for rapid evolution if the benefits outweigh the cost. We recently showed that genetic background significantly influences how yeast cells respond to gene over-expression (OE), revealing that the fitness costs of CNV can vary substantially with genetic background in a common-garden environment. But the interplay between CNV tolerance and environment remains unexplored on a genomic scale. Here we measured the tolerance to gene OE in four genetically distinct

Identifiers

PMID37503218
PMCPMC10369901
OpenAlexW4376617951

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.