Evidence map›Paper›PMID 37503212›Full record

ArticlebioRxiv : the preprint server for biology2023

Human Cytomegalovirus in breast milk is associated with milk composition, the infant gut microbiome, and infant growth.

Kelsey E Johnson, Timothy Heisel, David A Fields, Elvira Isganaitis, Katherine M Jacobs, Dan Knights, Eric F Lock, Michael C Rudolph, Cheryl A Gale, Mark R Schleiss and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Kelsey E JohnsonDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, USA.
Timothy HeiselDivision of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
David A FieldsDepartment of Pediatrics, Diabetes-Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Elvira IsganaitisPediatric, Adolescent and Young Adult Unit, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Katherine M JacobsDepartment of Obstetrics, Gynecology and Women's Health, Division of Maternal-Fetal Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Dan KnightsBioTechnology Institute, College of Biological Sciences, University of Minnesota, Minneapolis, MN, USA.
Eric F LockDivision of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN, USA.
Michael C RudolphHarold Hamm Diabetes Center, Department of Physiology, Oklahoma University Health Sciences Center, Oklahoma City, OK, USA.
Cheryl A GaleDivision of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Mark R SchleissDivision of Pediatric Infectious Diseases and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Frank W AlbertDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, USA.
Ellen W DemerathDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
Ran BlekhmanSection of Genetic Medicine, Division of Biological Sciences, University of Chicago, Chicago, IL, USA.
University of Minnesota · USUniversity of Minnesota Medical Center · USJoslin Diabetes Center · USOU HealthUniversity of Chicago · USUniversity of Oklahoma Health Sciences Center · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI LORI M LAFFEL · 1986 to 2026
$50.5M
ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8M
Maternal Obesity, Milk Composition, and Infant GrowthR01HD080444 · NICHD · UNIVERSITY OF MINNESOTA · PI ELLEN W. DEMERATH, DAVID A FIELDS · 2014 to 2026
$6.4M
Milk-Omics: Systems Biology of Human Milk and Its Links to Maternal and Infant HealthR01HD109830 · NICHD · UNIVERSITY OF MINNESOTA · PI Ran Blekhman, ELLEN W. DEMERATH · 2022 to 2026
$3.5M
Gut Microbiomes and Early Human NeurodevelopmentR21HD099473 · NICHD · UNIVERSITY OF MINNESOTA · PI GALE, CHERYL A., GEORGIEFF, MICHAEL K. · 2019 to 2020
$424k
Genetics and genomics of human breast milk compositionF32HD105364 · NICHD · UNIVERSITY OF MINNESOTA · PI JOHNSON, KELSEY ELIZABETH · 2021 to 2023
$165k
NICHD NIH HHS F32 HD105364NICHD NIH HHS R01 HD080444NICHD NIH HHS R01 HD109830NICHD NIH HHS R21 HD099473NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK042086
6 · The paper itself

Abstract

Human cytomegalovirus (CMV) is a highly prevalent herpesvirus that is often transmitted to the neonate via breast milk. Postnatal CMV transmission can have negative health consequences for preterm and immunocompromised infants, but any effects on healthy term infants are thought to be benign. Furthermore, the impact of CMV on the composition of the hundreds of bioactive factors in human milk has not been tested. Here, we utilize a cohort of exclusively breastfeeding full term mother-infant pairs to test for differences in the milk transcriptome and metabolome associated with CMV, and the impact of CMV in breast milk on the infant gut microbiome and infant growth. We find upregulation of the indoleamine 2,3- dioxygenase (IDO) tryptophan-to-kynurenine metabolic pathway in CMV+ milk samples, and that CMV+ milk is associated with decreased

Identifiers

PMID37503212
PMCPMC10370112
OpenAlexW4384932870

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.