Evidence map›Paper›PMID 37503194›Full record

ArticlebioRxiv : the preprint server for biology2023

An epigenome-wide association study of child appetitive traits and DNA methylation.

Holly A Harris, Chloe Friedman, Anne P Starling, Dana Dabelea, Susan L Johnson, Bernard F Fuemmeler, Dereje Jima, Susan K Murphy, Cathrine Hoyo, Pauline W Jansen and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Holly A HarrisDepartment of Child & Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Chloe FriedmanDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Anne P StarlingDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Dana DabeleaDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Susan L JohnsonDepartment of Pediatrics, Section of Nutrition, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Bernard F FuemmelerVirginia Commonwealth University, Mase Comprehensive Cancer Center, Richmond, VA, USA.
Dereje JimaBioinformatics Research Center, North Carolina State University, Raleigh, NC, USA.
Susan K MurphyDuke University Medical Center, Department of Obstetrics and Gynecology, Reproductive Sciences, Durham, NC, USA.
Cathrine HoyoDepartment of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA.
Pauline W JansenDepartment of Child & Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Rosa MulderThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Erasmus MC · NLColorado School of Public Health · USNorth Carolina State University · USDuke Medical Center · USUniversity of Colorado Anschutz Medical Campus · USUniversity of North Carolina at Chapel Hill · USVirginia Commonwealth University · US

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Venkata Saroja Voruganti · 1999 to 2026
$31.6M
The Early Life Exposome and Childhood Health - The Colorado Healthy Start 3 Cohort StudyUH3OD023248 · OD · UNIVERSITY OF COLORADO DENVER · PI Traci Allison Bekelman, Dana Dabelea · 2018 to 2026
$14.8M
Exploring the Fuel-Mediated Programming of Neonatal GrowthR01DK076648 · NIDDK · UNIVERSITY OF COLORADO DENVER/HSC DENVER · PI DABELEA, DANA · 2009 to 2018
$7.0M
The Early Life Exposome and Childhood Health - The Colorado Healthy Start 3 Cohort StudyUG3OD023248 · OD · UNIVERSITY OF COLORADO DENVER · PI BEKELMAN, TRACI ALLISON, DABELEA, DANA · 2016 to 2024
$5.9M
Endocrine disruptors, epigenetic programming and neonatal outcomesR01ES022934 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI ADGATE, JOHN L., DABELEA, DANA · 2014 to 2017
$2.3M
Epigenetic Pathways to Conduct Problem Trajectories: Early Environmental RisksR01HD068437 · NICHD · KING'S COLLEGE LONDON · PI BARKER, EDWARD D., MILL, JONATHAN · 2012 to 2014
$1.1M
NICHD NIH HHS R01 HD068437NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK076648NIEHS NIH HHS R01 ES022934NIH HHS UG3 OD023248NIH HHS UH3 OD023248
6 · The paper itself

Abstract

Childhood appetitive traits are consistently associated with obesity risk, and yet their etiology is poorly understood. Appetitive traits are complex phenotypes which are hypothesized to be influenced by both genetic and environmental factors, as well as their interactions. Early-life epigenetic processes, such as DNA methylation (DNAm), may be involved in the developmental programming of appetite regulation in childhood. In the current study, we meta-analyzed epigenome-wide association studies (EWASs) of cord blood DNAm and early-childhood appetitive traits. Data were from two independent cohorts: the Generation R Study (

Indexed as

Appetitive traitschildhoodDNA methylationeating behaviorsepigeneticsEpigenome-wide association study

Identifiers

PMID37503194
PMCPMC10370073
OpenAlexW4384666327

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.