Evidence map›Paper›PMID 37503190›Full record

ArticlebioRxiv : the preprint server for biology2023

Exposure to early life stress impairs weight loss maintenance success in mice.

Rebecca M Foright, Tara E McQuillan, Jenna M Frick, Paige M Minchella, Brittni M Levasseur, Omar Tinoco, Lauryn Birmingham, Anneka E Blankenship, John P Thyfault, Julie A Christianson

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rebecca M ForightDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas.
Tara E McQuillanDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas.
Jenna M FrickDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas.
Paige M MinchellaDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas.
Brittni M LevasseurDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas.
Omar TinocoDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas.
Lauryn BirminghamDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas.
Anneka E BlankenshipDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas.
John P ThyfaultDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas.
Julie A ChristiansonDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas.
University of Kansas Medical Center · USVeterans Health Administration · US

Funding

Using PCORnet to Expand the DS-CONNECT Cohort Through Healthcare System Recruitment, Incorporating Electronic Health Records, and Assessing Self-DeterminationU54HD090216 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI COLOMBO, JOHN A. · 2016 to 2020
$6.2M
Effect of neonatal and adult stress on pelvic pain disorders and comorbidityR01DK099611 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CARLSTEN CHRISTIANSON, JULIE A · 2014 to 2024
$3.6M
Statins: Mitochondrial Function and Aerobic CapacityR01AR071263 · NIAMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NEUFER, P DARRELL, THYFAULT, JOHN P · 2017 to 2021
$3.0M
Metabolic Phenotyping ClusterS10OD028598 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI THYFAULT, JOHN P · 2020 to 2020
$602k
The Impact of Early Life Stress on Reward and Body WeightF32DK127693 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI FORIGHT, REBECCA · 2021 to 2023
$205k
Sexual dimorphism, hepatic mitochondrial adaptations, and hepatic steatosisI01BX002567 · VA · KANSAS CITY VA MEDICAL CENTER · PI THYFAULT, JOHN P · 2015 to 2025
–
BLRD VA I01 BX002567NIAMS NIH HHS R01 AR071263NICHD NIH HHS U54 HD090216NIDDK NIH HHS F32 DK127693NIDDK NIH HHS R01 DK099611NIH HHS S10 OD028598
6 · The paper itself

Abstract

Early life stress increases obesity risk, but its impact on weight loss maintenance is unknown. Mice underwent neonatal maternal separation (NMS) from 0-3 weeks and were weaned onto high fat sucrose diet (HFSD) from 3-20 weeks. Calorie-restricted weight loss on a low fat sucrose diet (LFSD) occurred over 2 weeks to induce a 20% loss in body weight, which was maintained for 6 weeks. After weight loss, half the mice received running wheels (EX) the other half remained sedentary (SED). Mice were then fed

Indexed as

exercisehigh fat sucrose dietstressweight regain

Identifiers

PMID37503190
PMCPMC10370125
OpenAlexW4384931178

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.