Evidence map›Paper›PMID 37503165›Full record

ArticlemedRxiv : the preprint server for health sciences2024

The effect of combining antibiotics on resistance: A systematic review and meta-analysis.

Berit Siedentop, Viacheslav N Kachalov, Christopher Witzany, Matthias Egger, Roger D Kouyos, Sebastian Bonhoeffer

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 11 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Berit SiedentopInstitute of Integrative Biology, Department of Environmental Systems Science, ETH Zürich, Zurich, Switzerland.ORCID 0000-0003-0802-7681
Viacheslav N KachalovDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, University of Zürich, Zürich, Switzerland.ORCID 0000-0002-0310-3764
Christopher WitzanyInstitute of Integrative Biology, Department of Environmental Systems Science, ETH Zürich, Zurich, Switzerland.ORCID 0000-0002-7128-6419
Matthias EggerInstitute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.ORCID 0000-0001-7462-5132
Roger D KouyosDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich, University of Zürich, Zürich, Switzerland.ORCID 0000-0002-9220-8348
Sebastian BonhoefferInstitute of Integrative Biology, Department of Environmental Systems Science, ETH Zürich, Zurich, Switzerland.ORCID 0000-0001-8052-3925
University of Zurich · CHETH Zurich · CHUniversity of Bern · CH

Funding

Observational Antiretroviral Studies In Southern Africa (OASIS) CollaborationU01AI069924 · NIAID · UNIVERSITAT BERN · PI Cleophas Chimbetete, Mary-Ann Davies · 2006 to 2026
$55.9M
NIAID NIH HHS U01 AI069924
6 · The paper itself

Abstract

When and under which conditions antibiotic combination therapy decelerates rather than accelerates resistance evolution is not well understood. We examined the effect of combining antibiotics on within-patient resistance development across various bacterial pathogens and antibiotics. We searched CENTRAL, EMBASE and PubMed for (quasi)-randomised controlled trials (RCTs) published from database inception to November 24

Indexed as

antibiotic resistancecombination therapymeta-analysisresistance evolutionsystematic review

Identifiers

PMID37503165
PMCPMC10370225
OpenAlexW4384008332

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.