Evidence map›Paper›PMID 37503117›Full record

ArticlebioRxiv : the preprint server for biology2023

Insight into the structural hierarchy of the protease cascade that regulates the mosquito melanization response.

Sally A Saab, Xiufeng Zhang, Suheir Zeineddine, Bianca Morejon, Kristin Michel, Mike A Osta

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Sally A SaabDepartment of Biology, American University of Beirut, Beirut, Lebanon.
Xiufeng ZhangDivision of Biology, Kansas State University, Manhattan, KS, USA.
Suheir ZeineddineDepartment of Biology, American University of Beirut, Beirut, Lebanon.
Bianca MorejonDivision of Biology, Kansas State University, Manhattan, KS, USA.
Kristin MichelDivision of Biology, Kansas State University, Manhattan, KS, USA.ORCID 0000-0001-9769-5248
Mike A OstaDepartment of Biology, American University of Beirut, Beirut, Lebanon.

Funding

The protease network that regulates innate immunity in mosquitoesR01AI140760 · NIAID · KANSAS STATE UNIVERSITY · PI MICHEL, KRISTIN · 2018 to 2022
$2.8M
NIAID NIH HHS R01 AI140760
6 · The paper itself

Abstract

Serine protease cascades regulate important insect immune responses, including melanization and Toll pathway activation. In the context of melanization, central components of these cascades are clip domain serine proteases (CLIPs) including the catalytic, clip domain serine proteases (cSPs) and their non-catalytic homologs (cSPHs). Here, we define partially the structural hierarchy of

Indexed as

Anopheles gambiaeclip domain serine protease cascadesmelanizationmosquito innate immunity

Identifiers

PMID37503117
PMCPMC10369957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.